Preparation of siloxane-containing vaterite/poly (lactic acid) hybrid fibermats with improved ductility for bone regeneration
Preparation of siloxane-containing vaterite/poly (lactic acid) hybrid fibermats with improved ductility for bone regeneration
复制标题
含硅氧烷的球霰石/聚乳酸混合纤维垫的制备，其具有改善的延展性用于骨再生
DOI：
10.2109/jcersj2.118.623
复制
发表时间：
2010
影响因子：
1.1
通讯作者：
T. Kasuga
中科院分区：
文献类型：
--
作者：
Sen Lin;K. Fujikura;A. Obata;T. Kasuga
含硅氧烷的球文石（SiV）/聚（L-乳酸）（PLLA）杂化（SiPVH）纤维毡具有上级骨再生应用潜力。目前的工作旨在通过提高其机械性能并保持其生物活性来优化其作为骨填充材料的性能。采用熔融共混和静电纺丝工艺制备SiPVH纤维毡，并通过将PLLA含量从40重量%增加到70重量%进行改性。改性纤维毡的拉伸强度比原纤维毡提高了10倍以上。改性纤维毡的断裂前伸长率是原纤维毡的两倍。通过观察拉伸试验后纤维毡中的失效点来研究其增强的机制：发生在改性纤维毡中的纤维颈缩被认为有助于增强的机械性能。改性后的纤维毡在Tris缓冲溶液中释放出相对稳定的硅离子，并可通过模拟体液浸泡的方法在纤维毡表面包覆羟基磷灰石。
Siloxane-containing vaterite (SiV)/poly (L-lactic acid) (PLLA) hybrid (SiPVH) fibermats have superior potential for bone regeneration applications. Present work aims to optimise its performance as bone filler materials by improving its mechanical properties and maintaining its bioactivity. The SiPVH fibermats were prepared with melt-blending and electrospinning protocols and modified by increasing PLLA content from 40 to 70 wt %. The tensile strength of the modified fibermat was 10 times higher than that of the original one. The elongation before failure of the modified fibermat was twice as large as that of the original one. The mechanism of their enhancement was investigated by observing failure points in the fibermats after the tensile tests: necking of fibers, which occurred in the modified fibermats, was believed to contribute to the enhanced mechanical properties. The modified fibermat showed the relatively constant release of ionic silicon-species in Tris-buffer solution and could be coated with hydroxyapatite by soaking in simulated body fluid.