Photoacoustic ocular imaging.
Photoacoustic ocular imaging.
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DOI：
10.1364/ol.35.000270
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发表时间：
2010-02-01
期刊：
影响因子：
3.6
通讯作者：
Gambhir SS
中科院分区：
文献类型：
--
作者：
de la Zerda A;Paulus YM;Teed R;Bodapati S;Dollberg Y;Khuri-Yakub BT;Blumenkranz MS;Moshfeghi DM;Gambhir SS
我们开发了一种光声眼部成像设备，并证明了其在成像眼睛的深层，包括视网膜，脉络膜和视神经的效用。使用安全的激光强度，光声系统能够可视化去核猪的眼睛和活体兔子的眼睛的血液分布。同时获得的超声图像叠加在光声图像上，以可视化眼睛的解剖结构。这种系统将来可能用于新生血管性眼部疾病的早期检测和改善管理，包括湿性年龄相关性黄斑变性和增殖性糖尿病视网膜病变。
We developed a photoacoustic ocular imaging device and demonstrated its utility in imaging the deeper layers of the eye including the retina, choroid, and optic nerve. Using safe laser intensity, the photoacoustic system was able to visualize the blood distribution of an enucleated pig’s eye and an eye of a living rabbit. Ultrasound images, which were simultaneously acquired, were overlaid on the photoacoustic images to visualize the eye’s anatomy. Such a system may be used in the future for early detection and improved management of neovascular ocular diseases, including wet age-related macular degeneration and proliferative diabetic retinopathy.