Prolonged tedizolid use in cutaneous non-tuberculous mycobacterial infection.
Prolonged tedizolid use in cutaneous non-tuberculous mycobacterial infection.
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DOI：
10.1016/j.jctube.2021.100261
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发表时间：
2021-08
影响因子：
2
通讯作者：
Hunter M
中科院分区：
文献类型：
--
作者：
Shaw TD;Smyth M;Turner G;Hunter M
皮肤非结核分枝杆菌 (NTM) 感染是一种新出现的传染病，需要长期联合使用抗生素。抗菌药物的选择受到耐药性和毒性的限制。 Tedizolid 是一种新型恶唑烷酮抗生素，具有针对某些 NTM 的体外活性，但其在治疗肺外 NTM 中的用途尚未被描述。我们报告了利奈唑胺不耐受后长期使用泰地唑胺（8 个月）在艰难的龟分枝杆菌皮肤感染病例联合治疗中的效用。尽管泰地唑胺有助于临床缓解，但它也可能导致多灶性周围神经病变。其疗效也可能受到持续免疫抑制的限制，有证据表明联合治疗完成后疾病复发或治疗失败。对于皮肤 NTM 感染的疑难病例，可以谨慎考虑使用泰地唑胺进行联合治疗。
Cutaneous non-tuberculous mycobacterial (NTM) infections are an emerging infectious disease and require a protracted course of combination antibiotics. Antimicrobial choice is limited by resistance and toxicity. Tedizolid is a new oxazolidinone antibiotic with in vitro activity against some NTM, but its use in the management of extrapulmonary NTM has not been described. We report on the utility of prolonged tedizolid use (8 months), after linezolid intolerance, in combination therapy in a case of difficult Mycobacterium chelonae cutaneous infection. Although tedizolid contributed to clinical remission, it may have also contributed to a multifocal peripheral neuropathy. Its efficacy may also have been limited by continued immunosuppression, with evidence to suggest disease relapse or treatment failure after completion of combination therapy. Tedizolid can be considered, with caution, in combination therapy for difficult cases of cutaneous NTM infection.
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影响因子：
2.1
作者：
Longworth, Sarah A.;Daly, Jennifer S.
通讯作者：
Daly, Jennifer S.
影响因子：
5.2
作者：
Ruth, Mike Marvin;Koeken, Valerie A. C. M.;van Ingen, Jakko
通讯作者：
van Ingen, Jakko
影响因子：
11.8
作者：
Piersimoni C;Scarparo C
通讯作者：
Scarparo C
影响因子：
4.6
作者：
Biondi, Gabriele;Sotgiu, Giovanni;Satta, Rosanna
通讯作者：
Satta, Rosanna
DOI：
10.1056/nejmct0806956
发表时间：
2009-09-10
期刊：
The New England journal of medicine
影响因子：
--
作者：
Ziegler TR
通讯作者：
Ziegler TR