Stochastic Sensing of Polynucleotides Using Patterned Nanopores
Stochastic Sensing of Polynucleotides Using Patterned Nanopores
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DOI：
10.1103/physrevx.2.021002
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发表时间：
2012-04-05
影响因子：
12.5
通讯作者：
Golestanian, Ramin
中科院分区：
文献类型：
--
作者：
Cohen, Jack A.;Chaudhuri, Abhishek;Golestanian, Ramin
采用朗格万动力学模拟方法研究了孔隙微观结构对聚合物迁移的影响，并探讨了在孔隙中引入模式黏性的后果。研究发现，该易位过程对这种模式的详细结构非常敏感，易位时间对孔隙黏性的依赖速度快于指数。易位过程的随机性导致具有不同序列的聚合物如何通过特定图案的孔隙之间存在明显的差异。利用这一概念提出了一种多核苷酸随机传感协议，并证明该方法可以任意鲁棒，比现有方法快得多。
The effect of the microscopic structure of a pore on polymer translocation is studied using Langevin dynamics simulation, and the consequence of introducing patterned stickiness inside the pore is investigated. It is found that the translocation process is extremely sensitive to the detailed structure of such patterns with faster than exponential dependence of translocation times on the stickiness of the pore. The stochastic nature of the translocation process leads to discernible differences between how polymers with different sequences go through specifically patterned pores. This notion is utilized to propose a stochastic sensing protocol for polynucleotides, and it is demonstrated that the method, which would be significantly faster than the existing methods, could be made arbitrarily robust.