Diagnostic use of serum deoxyribonuclease I activity as a novel early-phase marker in acute myocardial infarction
Diagnostic use of serum deoxyribonuclease I activity as a novel early-phase marker in acute myocardial infarction
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DOI：
10.1161/01.cir.0000129232.61483.43
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发表时间：
2004-05-25
期刊：
影响因子：
37.8
通讯作者：
Yasuda, T
中科院分区：
文献类型：
--
作者：
Kawai, Y;Yoshida, M;Yasuda, T
背景-血清心肌标志物如肌酸激酶同工酶MB的延迟释放和早期心电图的不确定性改变阻碍了急性心肌梗死（AMI）发病后早期的诊断。因此，一个可靠的血清生化标志物的诊断AMI在非常早期phase.Methods和结果-血清样本收集与AMI，不稳定型心绞痛，稳定型心绞痛，和其他疾病的患者。测定患者血清脱氧核糖核酸酶I（DNase I）活性水平。AMI患者在出现症状后约3小时内观察到血清DNA酶I活性突然升高，活性水平显着更高（21.7 ± 5.10 U/L）与其他不稳定型心绞痛组比较（10.4 ± 4.41 U/L）、心绞痛（10.8 ± 3.70 U/L）和其他疾病（9.22 ± 4.16 U/L）。血清中的DNase I活性水平，然后表现出显着的时间依赖性下降，在12小时内，并已恢复到基础水平在24 hours.Conclusions -我们建议，血清DNase I活性可作为一种新的诊断标志物AMI的早期检测。
Background - The delayed release of serum cardiac markers such as creatine kinase isoenzyme MB and equivocal early electrocardiographic changes have hampered a diagnosis of acute myocardial infarction ( AMI) in the early phase after its onset. Therefore, a reliable serum biochemical marker for the diagnosis of AMI in the very early phase is desirable.Methods and Results - Serum samples were collected from the patients with AMI, unstable angina pectoris, stable angina pectoris, and other diseases. Levels of serum deoxyribonuclease I ( DNase I) activity in the patients were determined. An abrupt elevation of serum DNase I activity was observed within approximately 3 hours of the onset of symptoms in patients with AMI, with significantly higher activity levels (21.7 +/- 5.10 U/L) in this group compared with the other groups with unstable angina pectoris (10.4 +/- 4.41 U/L), angina pectoris (10.8 +/- 3.70 U/L), and other diseases (9.22 +/- 4.16 U/L). Levels of the DNase I activity in serum then exhibited a marked time-dependent decline within 12 hours and had returned to basal levels within 24 hours.Conclusions - We suggest that serum DNase I activity could be used as a new diagnostic marker for the early detection of AMI.