FREQUENCY-RESPONSE ANALYSIS OF CENTRAL VESTIBULAR UNIT ACTIVITY RESULTING FROM ROTATIONAL STIMULATION OF SEMICIRCULAR CANALS
FREQUENCY-RESPONSE ANALYSIS OF CENTRAL VESTIBULAR UNIT ACTIVITY RESULTING FROM ROTATIONAL STIMULATION OF SEMICIRCULAR CANALS
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DOI：
10.1113/jphysiol.1971.sp009657
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发表时间：
1971-01-01
影响因子：
5.5
通讯作者：
MILSUM, JH
中科院分区：
文献类型：
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作者：
JONES, GM;MILSUM, JH
1.猫前庭神经核半规管依赖性单位的神经反应在正弦旋转频率范围从0.004 Hz到0.9 Hz进行了检查。频率响应分析表明，在检查的范围内，脑干接收的神经信号中包含的信息与机械终末器官的预期信息相似。在实验频率范围内，发现神经响应和机械刺激之间的关系由约4秒的单个时间常数主导，使得可以在高于和低于1/4弧度/秒（100 Hz）的刺激频率下定义两个响应区域。高于该频率，神经信号的信息内容倾向于角速度，低于该频率，其倾向于角加速度。由此推断（a）猫的水平神经管的所谓“长”时间常数约为4秒，（B）在大多数频率低于1 Hz的正常头部运动中，神经管中产生的神经信号的信息模式和脑干中接收的神经信号的信息模式可能倾向于头部角速度。6.这似乎适用于产生前庭眼反射补偿头部运动和反射阻尼（负速度反馈）的意外头部和身体运动。7.中央单位反应的平均神经增益估计为1264动作电位/秒，每度的杯状偏转。这个高值反映了根据运河的物理特征评估的非常小的杯状偏转角度。根据计算结果，初步估计水平管中吸盘的弹性恢复系数为2·05 × 10 - 3dyne。厘米
1. The neural response of semicircular canal‐dependent units in the vestibular nuclei of cats has been examined over a frequency range of sinusoidal rotation extending from 0·004 to 0·9 Hz.2. Frequency—response analysis indicates that, over the range examined, the information contained in the neural signal received by the brain stem was similar to that expected from the mechanical end‐organ.3. Over the experimental frequency range, the relation between neural response and mechanical stimulus was found to be dominated by a single time constant of about 4 sec, such that two response regions can be defined above and below a stimulus frequency of ¼ rad/sec (≃ ≃ Hz).4. Above this frequency the information content of the neural signal tends towards that of angular velocity and below that frequency it tends towards that of angular acceleration.5. It is inferred (a) that the so‐called ‘long’ time constant of the cat's horizontal canal is about 4 sec and (b) that during most normal head movements containing frequencies below about 1 Hz the informational mode of neural signals generated in the canal and received in the brain stem probably tends towards that of head angular velocity.6. This seems appropriate for the generation of vestibulo‐ocular reflex compensation for head movement and for reflex damping (negative velocity feed‐back) of unintended head and body movements.7. The average neural gain of central unit responses is estimated at 1264 action potentials/sec, per degree of cupular deflexion. This high value reflects the very small angles of cupular deflexion assessed on the basis of physical characteristics of the canal.8. The results permit a rough estimate of the elastic restoring coefficient of the cupula in the horizontal canal as 2·05 × 10−3dyne. cm.