From molecular to nanotechnology strategies for delivery of neurotrophins: emphasis on brain-derived neurotrophic factor (BDNF).
From molecular to nanotechnology strategies for delivery of neurotrophins: emphasis on brain-derived neurotrophic factor (BDNF).
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DOI：
10.3390/pharmaceutics5010127
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发表时间：
2013-02-08
期刊：
影响因子：
5.4
通讯作者：
Lesieur S
中科院分区：
文献类型：
--
作者：
Géral C;Angelova A;Lesieur S
神经退行性疾病是一个主要的公共卫生问题，但尚未建立利用神经营养因子进行有益的临床治疗。神经营养素的治疗用途因其在生物介质中的不稳定性和快速降解而受到限制。人们提出了多种策略来施用这些主要候选治疗药物，这对于人类神经元的发育、存活和功能至关重要。在这篇综述中，我们描述了脑源性神经营养因子（BDNF）的现有递送方法，脑源性神经营养因子是哺乳动物中枢神经系统（CNS）中最丰富的神经营养因子。 BDNF 仿生肽已成为治疗神经退行性疾病的一种有前途的疗法。基于聚合物的载体提供了持续的神经营养素输送，而基于脂质的颗粒也有助于增强 BDNF 作用。纳米技术为神经保护和神经再生载体的设计提供了新的可能性。重点介绍了用于封装和运输 BDNF 的纳米级载体的最新进展。
Neurodegenerative diseases represent a major public health problem, but beneficial clinical treatment with neurotrophic factors has not been established yet. The therapeutic use of neurotrophins has been restrained by their instability and rapid degradation in biological medium. A variety of strategies has been proposed for the administration of these leading therapeutic candidates, which are essential for the development, survival and function of human neurons. In this review, we describe the existing approaches for delivery of brain-derived neurotrophic factor (BDNF), which is the most abundant neurotrophin in the mammalian central nervous system (CNS). Biomimetic peptides of BDNF have emerged as a promising therapy against neurodegenerative disorders. Polymer-based carriers have provided sustained neurotrophin delivery, whereas lipid-based particles have contributed also to potentiation of the BDNF action. Nanotechnology offers new possibilities for the design of vehicles for neuroprotection and neuroregeneration. Recent developments in nanoscale carriers for encapsulation and transport of BDNF are highlighted.