Differential behavioral responses to chronic amphetamine in adult male and female rats exposed to postnatal cocaine treatment
Differential behavioral responses to chronic amphetamine in adult male and female rats exposed to postnatal cocaine treatment
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DOI：
10.1016/s0091-3057(01)00545-7
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发表时间：
2001-05-01
影响因子：
3.6
通讯作者：
Dow-Edwards, DL
中科院分区：
文献类型：
--
作者：
Melnick, SM;Dow-Edwards, DL
通过反复间歇性服用安非他明后的运动活动和刻板印象，研究了发育期间可卡因暴露对行为敏感化的影响。雄性和雌性Sprague-Dawley大鼠在出生后11-20天（PND）暴露于50 mg/kg/天的可卡因中，成年后（PND 193-212）每天注射7次2.0 mg/kg的安非他明。在第一次和第七次注射后评估运动活动和刻板行为。对照男性和女性在反复注射安非他明后表现出敏感行为，女性表现出更大的运动，而男性表现出更多的刻板印象。经可卡因预处理的雄性大鼠在反复注射安非他明后未能产生与DI受体活性抑制一致的致敏运动或刻板反应。经可卡因预处理的女性没有表现出致敏的运动反应，但在反复服用安非他明后确实表现出刻板印象的致敏。因此，产后可卡因治疗似乎对雄性和雌性大鼠的致敏行为回路产生了不同的影响。(C) 2001爱思唯尔科学公司版权所有。
The impact of cocaine exposure during development on behavioral sensitization as measured by locomotor activity and stereotypy following repeated intermittent administration of amphetamine is examined. Male and female Sprague-Dawley rats were exposed to cocaine at 50 mg/kg/day during postnatal days (PND) 11-20 and, as adults (PND 193-212), were administered seven daily injections of 2.0 mg/kg amphetamine. Both locomotor activity and stereotypic behavior were assessed following the first and seventh injections. Control males and females showed sensitized behavior following repeated amphetamine injections with females showing greater locomotion while males showed increased stereotypy. Male rats pretreated with cocaine failed to develop sensitized locomotor or stereotypic responses following repeated amphetamine injections consistent with dampened DI receptor activity. Females pretreated with cocaine did not show a sensitized locomotor response but did display sensitization of stereotypy following repeated amphetamine administration. Thus, it appears that postnatal cocaine treatment produces differential effects on the circuits mediating sensitization behavior in male and female rats. (C) 2001 Elsevier Science Inc. All rights reserved.