POLYPEPTIDE FACTORS REGULATING OSTEOGENESIS AND BONE-MARROW REPAIR
POLYPEPTIDE FACTORS REGULATING OSTEOGENESIS AND BONE-MARROW REPAIR
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DOI：
10.1002/jcb.240550313
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发表时间：
1994-07-01
影响因子：
4
通讯作者：
EINHORN, TA
中科院分区：
文献类型：
--
作者：
BAB, IA;EINHORN, TA
成骨生长多肽在体外调节骨细胞功能，在体内可能以自分泌、旁分泌或内分泌方式发挥作用。其中几种多肽以非活性形式存在于血液中。在消融后骨髓再生过程中，这些因子可能被激活，从血凝块中释放出来，并与局部产生的多肽一起介导这一过程的初始髓内/全身成骨阶段。然后，基质细胞表达的相同和/或其他多肽具有促进第二阶段再生的潜力，该阶段包括破骨细胞生成、短暂髓内骨的吸收和造血。这可能是一种间接的影响，因为这些多肽可以调节基质细胞中某些造血因子的表达。临床上，成骨生长多肽在骨质疏松症的治疗、植入骨手术、骨髓移植等方面具有潜在的作用。(C)1994年Wiley-Liss，Inc.
Osteogenic growth polypeptides regulate bone cell function in vitro and may act in vivo in an autocrine, paracrine, or endocrine manner. Several of these polypeptides are present in the blood in an inactive form. During postablation bone marrow regeneration these factors may be activated, released from the blood clot, and together with locally produced polypeptides mediate the initial intramedullary/systemic osteogenic phase of this process. Then, the same and/or other polypeptides expressed by stromal cells have the potential to promote the second phase of regeneration that consists of osteoclastogenesis, resorption of the transient intramedullary bone, and hemopoiesis. This may be an indirect influence since these polypeptides can regulate the stromal cell expression of some of the hemopoietic factors. Clinically, the osteogenic growth polypeptides that regulate osteogenesis and hemopoiesis have a potential role in osteoporosis therapy, implant bone surgery, and bone marrow transplantation. (C) 1994 Wiley-Liss, Inc.