New approaches for treating atrial fibrillation: Focus on autonomic modulation
New approaches for treating atrial fibrillation: Focus on autonomic modulation
复制标题
DOI：
10.1016/j.tcm.2019.10.009
复制
发表时间：
2020-10-01
影响因子：
9.3
通讯作者：
Stavrakis, Stavros
中科院分区：
文献类型：
--
作者：
Sohinki, Daniel;Stavrakis, Stavros
心房颤动（AF）是一个快速增长的临床问题，在常规实践中，无论是心脏病学家和全科医生。目前针对房颤的治疗方法包括抗心律失常药物治疗和导管消融。这些疗法有许多局限性和风险，在维持窦性心律和改善硬临床结果方面的长期疗效令人失望。正因为如此，人们对房颤患者寻求替代治疗策略的兴趣越来越大。本综述旨在强调新兴的房颤治疗方法，特别关注几种旨在调节自主神经系统的方法。这些疗法在早期临床前和临床试验中显示出希望，代表了标准房颤治疗的令人兴奋的替代方案。(C) 2019 Elsevier Inc.版权所有。
Atrial fibrillation (AF) is a rapidly growing clinical problem in routine practice, both for cardiologists as well as general practitioners. Current therapies aimed at the management of AF include anti-arrhythmic drug therapy and catheter ablation. These therapies have a number of limitations and risks, and have disappointing long-term efficacy in maintaining sinus rhythm and improving hard clinical outcomes. Because of this, there is growing interest in pursuing alternative management strategies in patients with AF. This review seeks to highlight emerging AF therapies, with a specific focus on several modalities aimed at modulation of the autonomic nervous system. These therapies have shown promise in early pre-clinical and clinical trials, and represent exciting alternatives to standard AF treatment. (C) 2019 Elsevier Inc. All rights reserved.