A proposal for an updated neuropsychopharmacological nomenclature
A proposal for an updated neuropsychopharmacological nomenclature
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DOI：
10.1016/j.euroneuro.2013.08.004
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发表时间：
2014-07-01
影响因子：
5.6
通讯作者：
Stahl, Stephen M.
中科院分区：
文献类型：
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作者：
Zohar, Joseph;Nutt, David J.;Stahl, Stephen M.
目前的精神药理学术语仍然停留在早期的科学认识上，未能反映当代的发展和知识，不能帮助临床医生为特定的患者选择最好的药物，并且往往会通过处方不反映他们确定的诊断的药物来混淆患者（例如，对抑郁症开“抗精神病药”）。四个主要的神经精神药理学学院（ECNP，ACNP，亚洲CNP和CINP）提出了一个新的模板，包括一个多轴药理学驱动的命名法，通过四次调查测试。模板有五个轴：1-类（主要药理学靶点和相关机制）; 2-家族（反映相关神经递质和机制）; 3-神经生物学活性; 4-疗效和主要副作用; 5-获批适应症。调查结果表明，临床医生发现现有的基于适应症的命名系统不令人满意，不直观，令人困惑，并对他们和患者产生怀疑。拟议的五轴模板旨在通过将药理学而不是适应症作为主轴来颠覆当前的使用，拟议的命名主要与轴1类相关，其他轴的使用将在很大程度上取决于临床医生寻求加深其参与的科学和临床基础的程度。一个显着比例的参与者在四次调查中赞成拟议的系统，类似的数字想进一步考虑的想法，只有一小部分（8.6%）是反对it. The拟议的五轴药理学命名模板是一个系统，可能会刷新和反映当前的科学概念的神经精神药理学。(C)2014作者由爱思唯尔公司出版
Current psychopharmacological nomenclature remains wedded in an earlier period of scientific understanding, failing to reflect contemporary developments and knowledge, does not aid clinicians in selecting the best medication for a given patient, and tends to confuse patients by prescribing a drug that does not reflect their identified diagnosis (e.g. prescribe "antipsychotics" to depression). Four major colleges of Neuropsychopharmacology (ECNP, ACNP, Asian CNP and CINP) proposed a new template comprising a multi-axial pharmacologically-driven nomenclature tested by four surveys. The template has five axes: 1-class (primary pharmacological target and relevant mechanism); 2-family (reflecting the relevant neurotransmitter and mechanism); 3-neurobiological activities; 4-efficacy and major side effects; and 5-approved indications. The results of the surveys suggest that the clinicians found the available indication-based nomenclature system dissatisfactory, non-intuitive, confusing, and doubt-inducing for them and the patients. The proposed five-axis template seeks to upend current usage by placing pharmacology rather than indication as the primary axes, with the proposed nomenclature relating primarily to Axis-1 the class, and usage of the other axes would largely depend upon the extent to which the clinician seeks to deepen the scientific and clinical base of his involvement. A significant proportion of the participants in the four surveys were in favour of the proposed system, a similar number wanted to consider the idea further, and only a small proportion (8.6%) were against it. The proposed five-axis pharmacology based nomenclature template is a system which might refresh and reflect the current scientific concepts of neuropsychopharmacology. (C) 2014 The Authors. Published by Elsevier B.V.