The treatment of chondral and osteochondral defects of the knee with autologous matrix-induced chondrogenesis (AMIC): method description and recent developments
The treatment of chondral and osteochondral defects of the knee with autologous matrix-induced chondrogenesis (AMIC): method description and recent developments
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DOI：
10.1007/s00167-010-1356-1
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发表时间：
2011-08-01
影响因子：
3.8
通讯作者：
Behrens, Peter
中科院分区：
文献类型：
--
作者：
Benthien, Jan Philipp;Behrens, Peter
通过治疗软骨缺损进行的关节表面置换可包括软骨磨损、自体软骨细胞植入（ACI）、基质诱导软骨细胞移植（MACT）或骨软骨自体移植（OATS）。本技术报告描述了自体基质诱导软骨形成（AMIC）的方法，这是一种将软骨下微骨折与用纤维蛋白胶或缝线固定胶原I/III膜相结合的一步法。本技术报告介绍了AMIC手术及其进一步发展。该方法主要应用于膝关节的软骨或骨软骨病变。提供了适应症和禁忌症;描述了该技术。随着对软骨下区和软骨-骨复合体（骨软骨单位）的关注增加，AMIC的进一步发展也得到了描述，骨软骨单位在软骨研究中受到越来越多的关注。
Articular resurfacing by treatment of chondral defects may include chondral abrasion, autologous chondrocyte Implantation (ACI), matrix-induced chondrocyte transplantation (MACT) or osteochondral autologous transplantation (OATS). This technical note describes the method of autologous matrix-induced chondrogenesis (AMIC), a one-step procedure combining subchondral microfracture with the fixation of a collagen I/III membrane with fibrin glue or sutures.This is a technical note on the AMIC procedure and its further development.This method is applied primarily in chondral or osteochondral lesions of the knee. Indications and contraindications are provided; the technique is described. The further development of AMIC is described with an increased focus on the subchondral zone and the complex of cartilage and bone, the osteochondral unit, which receives increased attention in cartilage research.IV.