Phosphoinositide 3-kinases and regulation of embryonic stem cell fate
Phosphoinositide 3-kinases and regulation of embryonic stem cell fate
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DOI：
10.1042/bst0350225
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发表时间：
2007-04-01
影响因子：
3.9
通讯作者：
Bone, H. K.
中科院分区：
文献类型：
--
作者：
Welham, M. J.;Storm, M. P.;Bone, H. K.
胚胎干细胞系来源于胚胎着床前胚胎的外胚层，就像它们所衍生的内细胞群一样，表现出多能性的显著特性，即能够分化成构成成体的所有细胞系。胚胎干细胞及其分化的后代为再生医学提供了巨大的潜力，特别是作为治疗各种慢性疾病的细胞疗法，如1型糖尿病、帕金森病和视网膜变性。为了实现这一潜力，需要详细了解调节胚胎干细胞基本特性的分子机制，即多能性、增殖和分化。在本文中，我们回顾了PI3K （phosphoinositide 3-kinase）依赖性信号在ES细胞多能性和增殖调控中发挥作用的证据。
ES (embryonic stem) cell lines are derived from the epiblast of pre-implantation embryos and like the inner cell mass cells from which they are derived exhibit the remarkable property of pluripotency, namely the ability to differentiate into all cell lineages comprising the adult organism. ES cells and their differentiated progeny offer tremendous potential to regenerative medicine, particularly as cellular therapies for the treatment of a wide variety of chronic disorders, such as Type 1 diabetes, Parkinson's disease and retinal degeneration. In order for this potential to be realized, a detailed understanding of the molecular mechanisms regulating the fundamental properties of ES cells, i.e. pluripotency, proliferation and differentiation, is required. In the present paper, we review the evidence that PI3K (phosphoinositide 3-kinase)-dependent signalling plays a role in regulation of both ES cell pluripotency and proliferation.