Interaction of lipid vesicle with silver nanoparticle-serum albumin protein corona
Interaction of lipid vesicle with silver nanoparticle-serum albumin protein corona
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DOI：
10.1063/1.3672035
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发表时间：
2012-01-02
影响因子：
4
通讯作者：
Ke, Pu Chun
中科院分区：
文献类型：
--
作者：
Chen, Ran;Choudhary, Poonam;Ke, Pu Chun
The physical interaction between a lipid vesicle and a silver nanoparticle (AgNP)-human serum albumin (HSA) protein "corona" has been examined. Specifically, the binding of AgNPs and HSA was analyzed by spectrophotometry, and the induced conformational changes of the HSA were inferred from circular dichroism spectroscopy. The fluidity of the vesicle, a model system for mimicking cell membrane, was found to increase with the increased exposure to AgNP-HSA corona, though less pronounced compared to that induced by AgNPs alone. This study offers additional information for understanding the role of physical forces in nanoparticle-cell interaction and has implications for nanomedicine and nanotoxicology. (C) 2012 American Institute of Physics. [doi: 10.1063/1.3672035]
