Effect of sensory discrimination training on cortical reorganisation and phantom limb pain
Effect of sensory discrimination training on cortical reorganisation and phantom limb pain
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DOI：
10.1016/s0140-6736(00)04890-x
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发表时间：
2001-06-02
期刊：
影响因子：
168.9
通讯作者：
Grüsser, S
中科院分区：
文献类型：
--
作者：
Flor, H;Denke, C;Grüsser, S
幻肢痛是身体部分截肢的常见后果。基于幻肢痛与初级躯体感觉皮层的可塑性变化密切相关的发现，以及显示行为相关训练改变皮层地图的动物数据，我们为顽固性幻肢痛患者设计了一种感觉辨别训练方案。与对照组的药物治疗患者相比，训练组的幻肢痛（p=0.002）和皮质重组（p=0.05）显着减少，与改善的感觉辨别能力呈正相关。
Phantom limb pain is a frequent consequence of the amputation of a body part. Based on the finding that phantom limb pain is closely associated with plastic changes in the primary somatosensory cortex and animal data showing that behaviourally relevant training alters the cortical map, we devised a sensory discrimination training programme for patients with intractable phantom limb pain. Compared with a control group of medically treated patients, the training group had significant reductions in phantom limb pain (p=0.002) and cortical reorganisation (p=0.05) that were positively associated with improved sensory discrimination ability.