Off-line replay maintains declarative memories in a model of hippocampal-neocortical interactions
Off-line replay maintains declarative memories in a model of hippocampal-neocortical interactions
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DOI：
10.1038/nn1202
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发表时间：
2004-03-01
影响因子：
25
通讯作者：
Dayan, P
中科院分区：
文献类型：
--
作者：
Káli, S;Dayan, P
在睡眠期间，海马体和大脑皮层的神经活动似乎重现了早期清醒状态的某些方面。这种重播可能是巩固长期陈述性记忆的基础，从而使它们独立于海马体，并储存在新皮质中。与储存相反，良好的长期记忆的其他关键方面，如保持对储存痕迹的访问和对其正确解释的保存，几乎没有受到关注。我们在一个新皮质-海马区相互作用的理论模型中研究了长时情景记忆和语义记忆。我们发现，在缺乏规则的海马体重新激活的情况下，即使是理应巩固的情节记忆，面对皮质的语义可塑性也是脆弱的。重播允许通过将存储在海马体中的情节与变化的新皮质表征一起保持在适当的注册表中，从而保持对这些情节的访问。海马体的存储和回放在回忆结构化的语义信息方面也具有建设性的作用。
During sleep, neural activity in the hippocampus and neocortex seems to recapitulate aspects of its earlier, awake form. This replay may be a substrate for the consolidation of long-term declarative memories, whereby they become independent of the hippocampus and are stored in neocortex. In contrast to storage, other crucial facets of competent long-term memory, such as maintenance of access to stored traces and preservation of their correct interpretation, have received little attention. We investigate long-term episodic and semantic memory in a theoretical model of neocortical-hippocampal interaction. We find that, in the absence of regular hippocampal reactivation, even supposedly consolidated episodic memories are fragile in the face of cortical semantic plasticity. Replay allows access to episodes stored in the hippocampus to be maintained, by keeping them in appropriate register with changing neocortical representations. Hippocampal storage and replay also has a constructive role in the recall of structured, semantic information.