FIBRINOLYTIC-ACTIVITY, CLOTTING FACTORS, AND LONG-TERM INCIDENCE OF ISCHEMIC-HEART-DISEASE IN THE NORTHWICK-PARK-HEART-STUDY
FIBRINOLYTIC-ACTIVITY, CLOTTING FACTORS, AND LONG-TERM INCIDENCE OF ISCHEMIC-HEART-DISEASE IN THE NORTHWICK-PARK-HEART-STUDY
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DOI：
10.1016/0140-6736(93)92062-x
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发表时间：
1993-10-30
期刊：
影响因子：
168.9
通讯作者：
MILLER, GJ
中科院分区：
文献类型：
--
作者：
MEADE, TW;RUDDOCK, V;MILLER, GJ
1382名40-64岁的白人男性参加Northwick Park心脏研究时，通过稀释血凝块溶解时间测量了纤溶活性（FA），其中179人随后在平均16.1年的随访期间经历了缺血性心脏病发作。在缺血性心脏病方面，年龄和低FA之间存在显著的相互作用（p = 0.02）：在40-54岁的人群中，FA的一个标准差的差异与缺血性心脏病风险的约40%的差异（p = 0.002）相关。调整血浆纤维蛋白原后，FA相关性仍然存在。高纤维蛋白原浓度本身也与缺血性心脏病有关，正如高因子7活性与致命事件有关。年轻男性的低FA可能通过损害导致动脉粥样硬化的纤维蛋白沉积物的清除而产生长期影响。低FA似乎是年轻男性缺血性心脏病的主要决定因素，应该考虑通过改变生活方式或药物来增强纤溶活性的方法。
Fibrinolytic activity (FA) was measured by dilute blood clot lysis time at entry to the Northwick Park Heart Study in 1382 white men aged 40-64, of whom 179 subsequently experienced episodes of ischaemic heart disease during a mean follow-up period of 16.1 years.There was a significant interaction between age and low FA (p = 0.02) with respect to ischaemic heart disease: a difference of one standard deviation in FA was associated with a difference of about 40% in ischaemic heart disease risk (p = 0.002) in those aged 40-54 at entry. The FA association remained after adjusting for plasma fibrinogen. High fibrinogen concentrations themselves were also associated with ischaemic heart disease, as was high factor VII activity with fatal events. Low FA in younger men may exert a long-term influence by impairing the removal of fibrin deposits that contribute to atherogenesis.Low FA appears to be a leading determinant of ischaemic heart disease in younger men and methods of enhancing fibrinolytic activity, whether by life-style changes or pharmacologically, should be considered.