The role of the rat prelimbic/infralimbic cortex in working memory: Not involved in the short-term maintenance but in monitoring and processing functions
The role of the rat prelimbic/infralimbic cortex in working memory: Not involved in the short-term maintenance but in monitoring and processing functions
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DOI：
10.1016/j.neuroscience.2006.04.009
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发表时间：
2006-01-01
期刊：
影响因子：
3.3
通讯作者：
Delatour, B.
中科院分区：
文献类型：
--
作者：
Gisquet-Verrier, P.;Delatour, B.
与人类和灵长类动物相反，啮齿类动物的工作记忆通常被认为是一种简单的短时记忆缓冲区，主要采用延迟反应范式进行研究。本研究的目的是进一步研究大鼠前边缘/下边缘皮层在不同的空间延迟任务中的作用，以分离其参与临时存储从其他信息处理，如行为的灵活性和注意。在实验1中，大鼠在径向臂迷宫中进行标准消除winshift任务训练，之后在试验中期插入1分钟延迟。在引入延迟后，边缘/边缘下病变仅引起短暂的性能中断。在实验2中，大鼠直接训练在一个双赢的转变任务，5分钟的延迟，随后延长到30分钟。边缘/边缘下病变没有显着影响行为。然而，短暂中断的性能（与病变程度），反复注意到在病变大鼠时，干扰事件集。目前的研究结果表明，边缘前/边缘下皮层是不直接参与短期维护的具体信息，但涉及的变化时，如突然引入延迟或暴露于意外的干扰事件，改变初始情况。看来啮齿类动物的工作记忆应该像人类和灵长类动物一样，包括存储和监控功能。目前的结果和之前的结果沿着强烈表明，前边缘/边缘下皮质不参与临时在线存储，而是参与控制前瞻性组织正在进行的行动所需的信息。(c)2006年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Contrary to human and primate, working memory in the rodent is usually considered as a simple short term memory buffer and mainly investigated using delayed response paradigms. The aim of the present study was to further investigate the role of the rat prelimbic/infralimbic cortex in different spatial delayed tasks in order to dissociate its involvement in temporary storage from other information processes, such as behavioral flexibility and attention. In experiment 1 rats were trained in a standard elimination winshift task in a radial-arm maze after which a 1-min delay was inserted mid trial. Prelimbic/infralimbic lesions induced only a transient disruption of performance following introduction of the delay. In experiment 2, rats were trained directly in a win-shift task with a 5-min delay that was subsequently extended to 30 min. Prelimbic/infralimbic lesions did not significantly affect behavior. Nevertheless, transient disruptions of performance (correlated with lesion extent) were noted repeatedly in lesioned rats when sets of interfering events were presented. The present findings indicate that prelimbic/infralimbic cortex is not directly involved in the short term maintenance of specific information but is implicated when changes, such as sudden introduction of a delay or exposure to unexpected interfering events, alter the initial situation. It appears that working memory in rodents should be considered, as in humans and primates, to encompass both storage and monitoring functions. The present results along with previous ones strongly suggest that prelimbic/infralimbic cortex is not involved in the temporary on-line storage but rather in the control of information required to prospectively organize the ongoing action. (c) 2006 IBRO. Published by Elsevier Ltd. All rights reserved.