A new cyclic octopeptide from Schnabelia oligophylla
A new cyclic octopeptide from Schnabelia oligophylla
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发表时间：
2001-04
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通讯作者：
Y. Zhou;Mk Wang;S. Peng;L. Ding
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作者：
Y. Zhou;Mk Wang;S. Peng;L. Ding
取自寡叶SchnabeliaoligophyllaHand.-Mazz全草的甲醇提取物。通过硅胶层析分离出唇形科（Lamiaceae）的一种新的环状八肽，命名为schnabepeptide（1）。通过光谱分析阐明了其结构，并通过手性 HPLC 分析确定了除脯氨酸和甘氨酸之外的氨基酸单元的绝对构型。生物测定表明schnabepeptide (1) 对T/B 淋巴细胞具有免疫抑制活性。除新化合物外，还有七种已知化合物：octadeca-9, 16-dioxo-10(E),12(Z),14(E)-trienoic Acid (2), 12, 16-epoxy-11, 14-diHydroxy-17( 15-->16), 18 (4-->3)-diabeo-abieta-3,5,8,11,13,15-hexene-2, 7-二酮 (teuvincenone F, 3)、脱落酸 (4)、β-谷甾醇 (5)、胡萝卜甾醇 (6)、豆甾基 3-O-β -D-吡喃葡萄糖苷 (7) 和棕榈酸 (8) 也从该植物中分离出来。
From the methanol extract of the whole plant of Schnabelia oligophylla Hand.-Mazz. (Lamiaceae), a new cyclic octopeptide, named schnabepeptide (1), was isolated by silica gel chromatography. Its structure was elucidated by spectroscopic analyses and the absolute configuration of the amino acid units, except for proline and glycine, were assigned by chiral HPLC analysis. Bio-assay showed that schnabepeptide (1) exhibited an immunosuppression activity on T/B lymphocytes. Along with the new compound, seven known compounds, octadeca-9, 16-dioxo-10(E),12(Z),14(E)-trienoic acid (2), 12, 16-epoxy-11, 14-dihydroxy-17( 15-->16), 18 (4-->3)-diabeo-abieta-3,5,8,11,13,15-hexene-2, 7-dione (teuvincenone F, 3), abscisic acid (4), beta -sitosterol (5), daucosterol (6), stigmasteryl 3-O-beta -D-glucopyranoside (7) and palmitic acid (8), were also isolated from this plant.