Pyroptosis and its potential role in atherosclerosis
Pyroptosis and its potential role in atherosclerosis
复制标题
焦亡及其在动脉粥样硬化中的潜在作用
DOI：
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Wang Qian
中科院分区：
文献类型：
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作者：
Xu Yuanjun;Zheng Lei;Hu Yanwei;Wang Qian
焦亡是受调节的细胞死亡的促炎形式，并且依赖于属于半胱氨酸依赖性谷氨酸特异性蛋白酶（半胱天冬酶）家族的炎性蛋白酶的酶活性。焦亡在形态学、机制学和病理生理学上不同于其他形式的细胞死亡，包括凋亡和坏死。Pyroptosis的特征是细胞膜迅速破裂，释放细胞内物质和促炎介质，包括白细胞介素（IL）-1β、IL-18和Alarmin HMGB-1。近年来研究表明，Pyroptosis可能参与动脉粥样硬化的发生，并在动脉粥样硬化病变的不稳定性中发挥重要作用。在这里，我们回顾了在了解焦亡的形态学、分子和病理生理机制及其在动脉粥样硬化中的潜在作用方面取得的进展。
Pyroptosis is a pro-inflammatory form of regulated cell death and is dependent on the enzymatic activity of inflammatory proteases that belong to the family of cysteine-dependent aspartate-specific proteases (caspases). Pyroptosis is morphologically, mechanistically, and pathophysiologically distinct from other forms of cell death, including apoptosis and necrosis. Pyroptosis is characterized by rapid plasma membrane rupture, with the consequent release of intracellular contents and pro-inflammatory mediators, including interleukin (IL)-1β, IL-18, and the alarmin HMGB-1.Recent studies have shown that pyroptosis may be involved in atherosclerosis and play an important role in atherosclerotic lesion instability. Here, we review the progress made in understanding the morphological, molecular, and pathophysiological mechanisms of pyroptosis and its potential role in atherosclerosis.