Ultrafast Doppler Imaging of Blood Flow Dynamics in the Myocardium
Ultrafast Doppler Imaging of Blood Flow Dynamics in the Myocardium
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DOI：
10.1109/tmi.2012.2203316
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发表时间：
2012-08-01
影响因子：
10.6
通讯作者：
Tanter, Mickael
中科院分区：
文献类型：
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作者：
Osmanski, Bruno-Felix;Pernot, Mathieu;Tanter, Mickael
心肌内血管血流的实时成像有助于更好地诊断心血管疾病。迄今为止，没有一种标准的成像模式能够以良好的空间和时间分辨率准确地描述心肌血流动力学。我们最近介绍了一种新的超声多普勒成像技术的基础上复合平面波传输在超快帧速率。这种超快多普勒技术的高灵敏度允许对心肌内血流及其动力学进行成像。实现专用解调滤波过程以补偿心动周期期间心肌的大组织速度。带符号的功率多普勒处理提供动脉和静脉流之间的区分。使用放置在心脏表面的传统超声探头在大型动物开胸模型（N = 5只绵羊）中进行体内实验。结果表明，该技术的能力，以良好的空间（200 μ m）和时间分辨率（10毫秒）在正常生理条件下的心肌内血管流动的图像。研究了心动周期内的血流动力学，成像方法显示动脉和静脉血流之间的血流波形相位相反。最后，超快多普勒结合组织运动补偿被发现能够揭示主对角冠状动脉闭塞期间缺血区域的血管血流中断。
Imaging intramyocardial vascular flows in real-time could strongly help to achieve better diagnostic of cardiovascular diseases. To date, no standard imaging modality allows describing accurately myocardial blood flow dynamics with good spatial and temporal resolution. We recently introduced a novel ultrasonic Doppler imaging technique based on compounded plane waves transmissions at ultrafast frame rate. The high sensitivity of this ultrafast Doppler technique permits to image the intramyocardial blood flow and its dynamics. A dedicated demodulation-filtering process is implemented to compensate for the large tissue velocity of the myocardium during the cardiac cycle. A signed power Doppler processing provides the discrimination between arterial and venous flows. Experiments were performed in vivo in a large animal open chest model (N = 5 sheep) using a conventional ultrasonic probe placed at the surface of the heart. Results show the capability of the technique to image intramyocardial vascular flows in normal physiological conditions with good spatial (200 mu m) and temporal resolution (10 ms). Flow dynamics over the cardiac cycle were investigated and the imaging method demonstrated a phase opposition of flow waveforms between arterial and venous flows. Finally, ultrafast Doppler combined with tissue motion compensation was found able to reveal vascular flow disruption in ischemic regions during occlusion of the main diagonal coronary artery.