Degenerately Hydrogen Doped Molybdenum Oxide Nanodisks for Ultrasensitive Plasmonic Biosensing
Degenerately Hydrogen Doped Molybdenum Oxide Nanodisks for Ultrasensitive Plasmonic Biosensing
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DOI：
10.1002/adfm.201706006
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发表时间：
2018-03-14
影响因子：
19
通讯作者：
Ou, Jian Zhen
中科院分区：
文献类型：
--
作者：
Zhang, Bao Yue;Zavabeti, Ali;Ou, Jian Zhen
基于贵金属的等离子体生物传感器通常在环境折射率扰动不显著的情况下遭受低灵敏度。相比之下，简并掺杂半导体的特征通过允许基于电荷的检测为等离子体生物传感提供了新的维度。在这里，这个概念是证明在等离子体激元氢掺杂的钼氧化物（HxMoO 3），与2D纳米盘的形态，使用一个代表性的酶促葡萄糖传感模型。基于钼氧化物纳米盘对H+的吸附能力，HxMoO 3的等离子体共振波长被移动到可见-近红外波长。这些等离子体特征作为嵌入的H+浓度的函数显著改变。HxMoO 3的H+脱嵌提供了对酶促氧化过程中电荷扰动的特殊灵敏度和快速动力学。在H1.55MoO3处发现了最佳传感响应，即使当生物传感平台被适配成发光二极管光电探测器设置时，在410 nm处也实现了2 × 10（-9）m的检测限。与所有先前报道的等离子体酶促葡萄糖传感器相比，该性能上级，为开发高性能生物传感器提供了很好的机会。
Plasmonic biosensors based on noble metals generally suffer from low sensitivities if the perturbation of refractive-index in the ambient is not significant. By contrast, the features of degenerately doped semiconductors offer new dimensions for plasmonic biosensing, by allowing charge-based detection. Here, this concept is demonstrated in plasmonic hydrogen doped molybdenum oxides (HxMoO3), with the morphology of 2D nanodisks, using a representative enzymatic glucose sensing model. Based on the ultrahigh capacity of the molybdenum oxide nanodisks for accommodating H+, the plasmon resonance wavelengths of HxMoO3 are shifted into visible-near-infrared wavelengths. These plasmonic features alter significantly as a function of the intercalated H+ concentration. The facile H+ deintercalation out of HxMoO3 provides an exceptional sensitivity and fast kinetics to charge perturbations during enzymatic oxidation. The optimum sensing response is found at H1.55MoO3, achieving a detection limit of 2 x 10(-9)m at 410 nm, even when the biosensing platform is adapted into a light-emitting diode-photodetector setup. The performance is superior in comparison to all previously reported plasmonic enzymatic glucose sensors, providing a great opportunity in developing high performance biosensors.