PREVALENCE OF SERUM ANTIBODIES AGAINST THE P53 TUMOR-SUPPRESSOR GENE PROTEIN IN VARIOUS CANCERS
PREVALENCE OF SERUM ANTIBODIES AGAINST THE P53 TUMOR-SUPPRESSOR GENE PROTEIN IN VARIOUS CANCERS
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DOI：
10.1002/ijc.2910580404
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发表时间：
1994-08-15
影响因子：
6.4
通讯作者：
BUNTING, PS
中科院分区：
文献类型：
--
作者：
ANGELOPOULOU, K;DIAMANDIS, EP;BUNTING, PS
我们建立了两种新的定量检测人血清中抗p53抗体的方法。使用这些方法，我们分析了1,392例各种恶性肿瘤患者的血清和230例非恶性肿瘤患者的血清。抗p53抗体的最高流行率与卵巢癌和结肠癌（15%）相关，其次是肺癌（8%）和乳腺癌（5%）。其他恶性肿瘤的患病率较低（
We have developed 2 new quantitative methods for measuring anti-p53 antibodies in human serum. Using these methods we analyzed 1,392 sera from patients with various malignancies and 230 sera from individuals without malignancy. Highest prevalence of anti-p53 antibodies was associated with ovarian and colon cancers (15%), followed by lung (8%) and breast (5%) cancers. Prevalence in other malignancies was lower (