Gabab receptor-mediated modulation of glutamate signaling in cerebellar Purkinje cells
Gabab receptor-mediated modulation of glutamate signaling in cerebellar Purkinje cells
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DOI：
10.1080/14734220600788911
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
T. Tabata;M. Kano
中科院分区：
文献类型：
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作者：
T. Tabata;M. Kano
由于浦肯野细胞是小脑皮质的唯一输出神经元，在该细胞类型中兴奋性和抑制性突触输入的突触后整合是小脑运动信息处理的关键步骤。在浦肯野细胞中，Gi/o蛋白偶联的B型γ-氨基丁酸受体(GABABR)表达于由平行纤维的谷氨酸能终末支配的树突棘的环部。GABABR的亚细胞定位提示了GABABR和谷氨酸信号在突触后相互作用的可能性。最近的研究表明，GABABR确实可以调节α氨基-3-羟基-5-甲基-4-异氧酮丙酸型离子型谷氨酸受体和1型代谢型谷氨酸受体介导的信号转导。有趣的是，GABABR不仅通过经典的依赖于Gi/o蛋白的信号级联途径发挥调节作用，而且还通过GABR和mGluR1之间不依赖于Gi/o蛋白的相互作用发挥调节作用。在这篇综述中，我们比较了GABR的生理性质、潜在机制和可能的功能意义
Since Purkinje cells are the sole output neurons of the cerebellar cortex, the postsynaptic integration of excitatory and inhibitory synaptic inputs in this cell type is a pivotal step for cerebellar motor information processing. In Purkinje cells, Gi/o protein-coupled B-type γ-aminobutyric acid receptor (GABABR) is expressed at the annuli of the dendritic spines that are innervated by the glutamatergic terminals of parallel fibers. The subcellular localization of GABABR suggests the possibility of postsynaptic interplay between GABABR and glutamate signaling. It has recently been demonstrated that GABABR indeed modulates α amino-3-hydroxy-5-methyl-4-isoxalone propionate-type ionotropic glutamate receptor (AMPAR)-mediated and type-1 metabotropic glutamate receptor (mGluR1)-mediated signaling. Interestingly, GABABR exerts modulatory actions not only via the classical Gi/o protein-dependent signaling cascade but also via a Gi/o protein-independent interaction between GABABR and mGluR1. In this review, we compare the physiological nature, underlying mechanisms, and possible functional significance of these modulatory actions of GABABR