PLASMA-CORTISOL AND NATURAL-KILLER CELL-ACTIVITY DURING BEREAVEMENT
PLASMA-CORTISOL AND NATURAL-KILLER CELL-ACTIVITY DURING BEREAVEMENT
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DOI：
10.1016/0006-3223(88)90272-7
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发表时间：
1988-06-01
影响因子：
10.6
通讯作者：
WEINER, H
中科院分区：
文献类型：
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作者：
IRWIN, M;DANIELS, M;WEINER, H
自然杀伤细胞(NK)活性在抵御肿瘤和病毒感染方面非常重要，但在丧偶的女性中，这种活性会降低。在三组受试者中，研究了NK活性与血浆皮质醇的关系：预期丈夫死亡的女性、丈夫最近去世的女性和对照组。与对照组相比，失去亲人的妇女显示出NK活性降低和血浆皮质醇水平升高。预期失去亲人的妇女也显示出NK活性显著降低，但血浆皮质醇水平与对照组相当。在预期的和实际的丧亲期间，NK活性的降低不能仅仅基于皮质醇分泌的增加来解释。
Natural killer cell (NK) activity, which is important in the defense against tumors and viral infections, is reduced in women undergoing conjugal bereavement. The relationship between NK activity and plasma cortisol was investigated in three groups of subjects: women who were anticipating the death of their husbands, women whose husbands had recently died, and controls. Bereaved women showed reduced NK activity and increased plasma cortisol levels as compared to controls. Anticipatory bereaved women also showed significant reductions in NK activity, but had levels of plasma cortisol comparable to those of controls. The reduction of NK activity during anticipatory and actual bereavement cannot be explained solely on the basis of increased cortisol secretion.