Mechanisms of Post-Infarct Left Ventricular Remodeling.
Mechanisms of Post-Infarct Left Ventricular Remodeling.
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DOI：
10.1016/j.ddmec.2007.12.006
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Kramer, Christopher M
中科院分区：
文献类型：
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作者：
French, Brent A;Kramer, Christopher M
继发于心肌梗死（MI）的心力衰竭仍然是发病率和死亡率的主要来源。MI后的长期结果可以在很大程度上根据其对左心室大小和形状的影响来定义（即，LV重塑）。三种主要机制导致LV重构：1）早期梗死扩展，2）随后的梗死扩展到邻近的非梗死心肌，3）远端LV的晚期肥大。预防心肌梗死后心力衰竭的未来发展不仅取决于确定针对这些机制的药物，还取决于能够评估对每种机制疗效的诊断技术。
Heart failure secondary to myocardial infarction (MI) remains a major source of morbidity and mortality. Long-term outcome after MI can be largely be defined in terms of its impact on the size and shape of the left ventricle (i.e., LV remodeling). Three major mechanisms contribute to LV remodeling: 1) early infarct expansion, 2) subsequent infarct extension into adjacent noninfarcted myocardium, and 3) late hypertrophy in the remote LV. Future developments in preventing post-MI heart failure will depend not only on identifying drugs targeting each of these individual mechanisms, but also on diagnostic techniques capable of assessing efficacy against each mechanism.