Observations of amino acid gain and loss during protein evolution are explained by statistical bias
Observations of amino acid gain and loss during protein evolution are explained by statistical bias
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DOI：
10.1093/molbev/msl010
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发表时间：
2006-07-01
影响因子：
10.7
通讯作者：
Pollock, DD
中科院分区：
文献类型：
--
作者：
Goldstein, RA;Pollock, DD
最近发表在《自然》杂志上的一篇手稿的作者声称，他们已经发现了蛋白质进化中氨基酸增减的“普遍趋势”。在这里，我们表明，这种普遍的趋势可以简单地解释为一个偏见，这是不可避免的在原始分析中使用的3分类树。我们证明，一个严格可逆的平衡模型，当用与《自然》手稿相同的方法分析时，会产生相同的(在这种情况下，显然是错误的)结论。偏差的一个主要来源是将序列数据分成“信息性”和“非信息性”两个位置，这有利于观察某些转变。
The authors of a recent manuscript in "Nature" claim to have discovered "universal trends" of amino acid gain and loss in protein evolution. Here, we show that this universal trend can be simply explained by a bias that is unavoidable with the 3-taxon trees used in the original analysis. We demonstrate that a rigorously reversible equilibrium model, when analyzed with the same methods as the "Nature" manuscript, yields identical (and in this case, clearly erroneous) conclusions. A main source of the bias is the division of the sequence data into "informative" and "noninformative" sites, which favors the observation of certain transitions.