Comparison of biomechanical and structural properties between human aortic and pulmonary valve
Comparison of biomechanical and structural properties between human aortic and pulmonary valve
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DOI：
10.1016/j.ejcts.2004.05.043
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发表时间：
2004-09-01
影响因子：
3.4
通讯作者：
Kasyanov, V
中科院分区：
文献类型：
--
作者：
Stradins, P;Lacis, R;Kasyanov, V
目的：肺动脉瓣自体移植物已被报道用于置换患病的主动脉瓣（Ross手术）的临床有效性。关于肺动脉瓣作为主动脉瓣长期替代品的机械和结构适用性的已发表数据有限。本研究的目的是比较主动脉瓣和肺动脉瓣的特性。研究方法：对11例无病理改变的人心脏瓣膜进行了主动脉瓣和肺动脉瓣的生物力学性能和结构的实验研究。采用单轴拉伸试验研究了84个样本（所有瓣膜元件：瓣尖、纤维环、连合、窦管连接部、窦）的生物力学性能。透射电镜和扫描电镜观察超微结构。结果如下：肺动脉瓣尖周向极限应力高于主动脉瓣（分别为2.78 +/- 1.05和1.74 +/- 0.29 MPa）。肺动脉瓣尖和主动脉瓣尖径向的极限应力几乎相同（分别为0.29 +/- 0.06和0.32 +/- 0.04 MPa）。在超微结构研究中，确定了每个结构单元的不同布局和密度。主动脉瓣和肺动脉瓣具有共同的超微结构特性。结论：主动脉瓣和肺动脉瓣之间的力学差异很小。超微结构研究表明，主动脉瓣和肺动脉瓣具有相似的结构元素和架构。本研究表明，肺动脉瓣在机械和结构上均适合用作主动脉瓣置换术。(C)2004 Elsevier B. V.保留所有权利。
Objective: Pulmonary valve autografts have been reported as clinically effective for replacement of diseased aortic valve (Ross procedure). Published data about pulmonary valve mechanical and structural suitability as a long-term substitute for aortic valve are limited. The aim of this study was to compare aortic and pulmonary valve properties. Methods: Experimental studies of biomechanical properties and structure of aortic and pulmonary valves were carried out on pathologically unchanged human heart valves, collected from 11 cadaveric hearts. Biomechanical properties of 84 specimens (all valve elements: cusps, fibrous ring, commissures, sinotubular junction, sinuses) were investigated using uniaxial tensile tests. Ultrastructure was studied using transmission and scanning electron microscopy. Results: Ultimate stress in circumferential direction for pulmonary valve cusps is higher than for aortic valve (2.78 +/- 1.05 and 1.74 +/- 0.29 MPa, respectively). Ultimate stress in radial direction for pulmonary and aortic cusps is practically the same (0.29 +/- 0.06 and 0.32 +/- 0.04 MPa, respectively). In ultrastructural study, different layout and density in each construction element are determined. The aortic and pulmonary valves have common ultrastructural properties. Conclusions: Mechanical differences between aortic and pulmonary valve are minimal. Ultrastructural studies show that the aortic and pulmonary valves have similar structural elements and architecture. This investigation suggests that the pulmonary valve can be considered mechanically and structurally suitable for use as an aortic valve replacement. (C) 2004 Elsevier B.V. All rights reserved.