Imaging Assessment of Endothelial Function: An Index of Cardiovascular Health.
Imaging Assessment of Endothelial Function: An Index of Cardiovascular Health.
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DOI：
10.3389/fcvm.2022.778762
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发表时间：
2022
影响因子：
3.6
通讯作者：
中科院分区：
文献类型：
--
作者：
内皮功能障碍是多种心血管疾病的关键早期机制，可以在较大的导管动脉和较小的阻力血管（微血管功能障碍）中观察到。内皮功能障碍的存在是心血管事件和死亡率的有力预测因素，内皮功能的评估可以帮助选择治疗方法并测试其反应。虽然测量冠状动脉内皮功能的金标准方法仍然是侵入性血管造影，但已经出现了几种用于研究冠状动脉和外周内皮功能的非侵入性成像技术。在这篇综述中，我们将探索和总结当前可用于临床和研究用途的内皮功能评估的侵入性和非侵入性方法，并讨论每种技术的优点、局限性和未来应用。
Endothelial dysfunction is a key early mechanism in a variety of cardiovascular diseases and can be observed in larger conduit arteries as well as smaller resistance vessels (microvascular dysfunction). The presence of endothelial dysfunction is a strong prognosticator for cardiovascular events and mortality, and assessment of endothelial function can aid in selecting therapies and testing their response. While the gold standard method of measuring coronary endothelial function remains invasive angiography, several non-invasive imaging techniques have emerged for investigating both coronary and peripheral endothelial function. In this review, we will explore and summarize the current invasive and non-invasive modalities available for endothelial function assessment for clinical and research use, and discuss the strengths, limitations and future applications of each technique.