Anaphylaxis Induced by Peptide Coupling Agents: Lessons Learned from Repeated Exposure to HATU, HBTU, and HCTU
Anaphylaxis Induced by Peptide Coupling Agents: Lessons Learned from Repeated Exposure to HATU, HBTU, and HCTU
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DOI：
10.1021/acs.joc.9b03280
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发表时间：
2020-02-07
影响因子：
3.6
通讯作者：
Nowick, James S.
中科院分区：
文献类型：
--
作者：
McKnelly, Kate J.;Sokol, William;Nowick, James S.
肽偶联剂具有特殊的危险，因为它们是免疫敏化剂。在这里，我们提出了由三种脲偶联剂 HATU、HBTU 和 HCTU 引起的过敏反应的案例研究，作为经常使用肽偶联剂的研究人员的警告。我们还提供了有关在研究实验室中更安全地处理偶联剂的建议。
Peptide coupling agents pose a special hazard because they are immune sensitizers. Here, we present a case study of anaphylaxis induced by three uronium coupling agents, HATU, HBTU, and HCTU, as a cautionary note for researchers who handle peptide coupling agents frequently. We also include recommendations for handling coupling agents more safely in the research laboratory.