Factors associated with oxidative stress in human populations
Factors associated with oxidative stress in human populations
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DOI：
10.1093/aje/kwf029
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发表时间：
2002-08-01
影响因子：
5
通讯作者：
Packer, L
中科院分区：
文献类型：
--
作者：
Block, G;Dietrich, M;Packer, L
生物分子的氧化可能在许多疾病的易感性中起作用。然而，很少有大规模的调查数据描述发生在人类身上的氧化损伤以及可能与之相关的人口、身体或营养因素。这些信息对于研究氧化应激在健康和疾病中的作用的研究的设计和分析至关重要。本文报告了298名19-78岁健康成人的两种脂质过氧化生物标志物丙二醛和F-2-异前列腺素水平的数据。这项研究于1998-1999年在加利福尼亚州的伯克利和奥克兰进行。根据这两个生物标志物的测量，性别是脂质过氧化的最强预测因子(p<；0.0001)；它比吸烟更强。C反应蛋白与脂质过氧化呈正相关(p=0.004)，与血浆胆固醇呈正相关。血浆抗坏血酸与两种生物标志物均呈显著负相关(p<；0.001)。血浆β-胡萝卜素也与F-2-异前列腺素有关。一旦抗坏血酸被包括在多变量模型中，其他血浆抗氧化剂与脂质过氧化生物标记物无关。未来的调查和流行病学研究应该至少测量一个氧化损伤的标记物，以及血浆抗坏血酸。这些数据将有助于更好地了解氧化剂和抗氧化剂在人类健康中所起的作用。
Oxidation of biomolecules may play a role in susceptibility to a number of diseases. However, there are few large-scale survey data describing oxidative damage that occurs in humans and the demographic, physical, or nutritional factors that may be associated with it. Such information is essential for the design and analysis of studies investigating the role of oxidative stress in health and disease. This paper presents data on levels of two biomarkers of lipid peroxidation, malondialdehyde and F-2-isoprostanes, in 298 healthy adults aged 19-78 years. The study was conducted in Berkeley and Oakland, California, in 1998-1999. Sex was the strongest predictor of lipid peroxidation as measured by both biomarkers (p < 0.0001); it was stronger than smoking. C-reactive protein was positively associated with lipid peroxidation (p = 0.004), as was plasma cholesterol. Plasma ascorbic acid had a strong inverse relation (p < 0.001) with both biomarkers. Plasma beta-carotene was also associated with F-2-isoprostanes. Other plasma antioxidants were not associated with lipid peroxidation biomarkers, once ascorbic acid was included in the multivariate model. Future surveys and epidemiologic studies should measure at least one marker of oxidative damage, as well as plasma ascorbic acid. These data would permit a better understanding of the role that oxidants and antioxidants play in the health of human populations.