Involvement of enterobactin in norepinephrine-mediated iron supply from transferrin to enterohaemorrhagic Escherichia coli
Involvement of enterobactin in norepinephrine-mediated iron supply from transferrin to enterohaemorrhagic Escherichia coli
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DOI：
10.1016/s0378-1097(03)00243-x
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发表时间：
2003-05-16
影响因子：
2.1
通讯作者：
Lyte, M
中科院分区：
文献类型：
--
作者：
Freestone, PPE;Haigh, RD;Lyte, M
细菌暴露于压力相关的儿茶酚胺激素家族的成员，主要是去甲肾上腺素，已被证明可以增加生长和毒性相关因子的产生。肠杆菌素合成和摄取的基因突变揭示了去甲肾上腺素刺激大肠杆菌O157：H7生长对肠杆菌素的绝对需求。去甲肾上腺素刺激E.大肠杆菌不能替代肠杆菌素。我们还表明，去甲肾上腺素促进铁穿梭转铁蛋白分子之间，从而使细菌铁载体肠杆菌素更容易获得铁的增长。这些结果提示了应激的激素输出可能影响肠出血性大肠杆菌的可能机制之一。大肠杆菌致病性(C)2003年，欧洲微生物学会联合会。由Elsevier Science B.V.出版，版权所有。
Exposure of bacteria to members of the stress-associated family of catecholamine hormones, principally norepinephrine, has been demonstrated to increase both growth and production of virulence-related factors. Mutation of genes for enterobactin synthesis and uptake revealed an absolute requirement for enterobactin in norepinephrine-stimulated growth of Escherichia coli O157:H7. The autoinducer produced by norepinephrine-stimulated E. coli could not substitute for enterobactin. We also demonstrate that norepinephrine promotes iron shuttling between transferrin molecules, thereby enabling the bacterial siderophore enterobactin to more readily acquire iron for growth. These results suggest one of the possible mechanisms by which the hormonal output of stress may affect enterohaemorrhagic E. coli pathogenicity. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.