The Fovea-Protective Impact of Double-Layer Sign in Eyes With Foveal-Sparing Geographic Atrophy and Age-Related Macular Degeneration.
The Fovea-Protective Impact of Double-Layer Sign in Eyes With Foveal-Sparing Geographic Atrophy and Age-Related Macular Degeneration.
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DOI：
10.1167/iovs.63.11.4
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发表时间：
2022-10-03
影响因子：
4.4
通讯作者：
中科院分区：
文献类型：
--
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本研究的目的是调查双层征（DLS）对中心凹保留的地图状萎缩（GA）和年龄相关性黄斑变性（AMD）患者的GA进展的影响。这是一个回顾性的连续病例系列，随访时间超过6个月，患有继发于AMD的中心凹保留GA。在第一次和最后一次访视时，在眼底自发荧光图像上测量中心凹保留区域的大小。评价每只眼睛在中心凹保留区域内是否存在DLS。我们根据保留中心凹区域内DLS的存在对眼睛进行分级，并比较两组之间GA的进展（DLS（+）与DLS（-））。我们确定了25只至少进行了2次随访的黄斑中心凹保留性GA患眼（两次随访之间的平均间隔= 22.7 ± 11.8个月）。基线时平均中心凹保留面积为1.74 ± 0.87 mm 2（范围= 0.42-4.14 mm 2），末次访视时为1.26 ± 0.75 mm 2（范围= 0.25-2.92 mm 2）。17只眼（65.3%）在中心凹保留区域内被分级为DLS（+）。与DLS（+）组（0.088 ± 0.052 mm/年; P = 0.04）相比，DLS（-）组（0.149 ± 0.078 mm/年）中GA向中央凹的平方根进展明显更快。DLS（-）组显示出比DLS（+）组更快的向心GA进展。我们的数据表明，DLS的存在下，在备用中心凹区可能是一个保护因素，对中心凹进展的GA与AMD的眼睛。
The purpose of this study was to investigate the impact of double-layer sign (DLS) on geographic atrophy (GA) progression in eyes with foveal-sparing GA and age-related macular degeneration (AMD). This is a retrospective, consecutive case series of eyes with foveal-sparing GA secondary to AMD with more than 6 months of follow-up. The size of the foveal-sparing area was measured on the fundus autofluorescence images at the first and last visits. Each eye was evaluated for the presence or absence of DLS inside the foveal-sparing area. We graded eyes based on the presence of DLS within the foveal-sparing area and compared the progression of GA between two groups (DLS (+) versus DLS (−)). We identified 25 eyes with foveal-sparing GA with at least 2 follow-up visits (average interval = 22.7 ± 11.8 months between visits). The mean foveal sparing area was 1.74 ± 0.87 mm2 (range = 0.42–4.14 mm2) at baseline and 1.26 ± 0.75 mm2 (range = 0.25–2.92 mm2) at the last visit. Seventeen eyes (65.3%) were graded as DLS (+) within the foveal-sparing area. Square root progression of GA toward the fovea was significantly faster in the DLS (−) eyes (0.149 ± 0.078 mm/year) compared to the DLS (+) group (0.088 ± 0.052 mm/year; P = 0.04). The DLS (−) group showed significantly faster centripetal GA progression than the DLS (+) group. Our data suggest that the presence of DLS in the spared foveal area could be a protective factor against foveal progression of GA in eyes with AMD.
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影响因子：
8.1
作者：
Colijn, Johanna M.;Liefers, Bart;Klaver, Caroline C. W.
通讯作者：
Klaver, Caroline C. W.
影响因子：
4.5
作者：
Chan, Clement K.;Lalezary, Maziar;Yiu, Glenn
通讯作者：
Yiu, Glenn
影响因子：
3.9
作者：
Ghanchi, Faruque D.;Fulcher, Corinne;Mdanat, Faris
通讯作者：
Mdanat, Faris
DOI：
10.1097/iae.0000000000003207
发表时间：
2021-12-01
影响因子：
3.3
作者：
Eshtiaghi, Arshia;Issa, Mariam;Kertes, Peter J.
通讯作者：
Kertes, Peter J.
影响因子：
13.7
作者：
Lindner, Moritz;Boeker, Alexander;Fleckenstein, Monika
通讯作者：
Fleckenstein, Monika