Increased vascularity of brain, heart, and skeletal muscle of polycythemic rats.
Increased vascularity of brain, heart, and skeletal muscle of polycythemic rats.
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红细胞增多症大鼠的大脑、心脏和骨骼肌的血管供应增加。
DOI：
10.1152/ajplegacy.1970.219.3.702
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发表时间：
1970
期刊：
影响因子：
--
通讯作者：
D. M. Hale
中科院分区：
文献类型：
--
作者：
A. T. Miller;D. M. Hale
米勒，A. T.，小R，和D. M.黑尔红细胞增多症大鼠的脑、心脏和骨骼肌血管分布增加。J. Physiol 21g（3）：702-704. 1970.-在暴露于18，000英尺的模拟海拔高度，或每天注射氯化钴，或每周两次输注红细胞悬液的大鼠中，测量大脑皮质、右心室和左心室以及腓肠肌的血管分布。在所有三组动物中观察到大脑皮质、左心室和腓肠肌的血管分布高度显著增加。高海拔暴露组右心室血管收缩率增加，而钴处理组和输血组则无此现象。在所有三组动物中，血管分布的增加与大脑皮质和腓肠肌中红细胞压积的增加成比例。在右心室和左心室中，与血细胞比容增加相关的血管分布增加在海拔暴露的动物中比在钴处理或输血的动物中更大。负责血管变化的刺激的性质尚未确定;这表明，增加血容量或血液粘度，以及组织缺氧，可能涉及。
MILLER, A. T., JR., AND D. M. HALE. Increased vascularity of brain, heart, and skeletal muscle of polycythemic rats, Am. J. Physiol 2 1 g(3) : 702-704. 1970.-The vascularity of the cerebral cortex, right and left ventricle, and gastrocnemius muscle was measured in rats exposed to a simulated altitude of 18,000 ft, or injected ,daily with cobalt chloride, or transfused twice weekly with erythrocyte suspensions. Highly significant increases in vascularity of the cerebral cortex, left ventricle, and gastrocnemius muscle were sobserved in all three groups of animals. Vascular&y of the right ventricle was increased in altitude-exposed, but not in cobalttreated or transfused animals. The increase in vascularity was proportional to the increase in hematocrit in cerebral cortex and gastrocnemius muscle in all three groups of animals. In both right and left ventricle, the increase in vascularity relative to the increase in hematocrit was greater in altitude-exposed animals than in cobalt-treated or transfused animals. The nature of the stimulus responsible for the vascular changes has not been identified; it is suggested that increased blood volume or blood viscosity, as well as tissue hypoxia, may be involved.