What light have resting state fMRI studies shed on cognition and mood in Parkinson's disease?
What light have resting state fMRI studies shed on cognition and mood in Parkinson's disease?
复制标题
帕金森氏病中关于认知和情绪的静止状态功能磁共振成像研究有什么光？
DOI：
10.1186/2054-7072-1-4
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Poston KL
中科院分区：
文献类型：
--
作者：
YorkWilliams S;Poston KL
关于帕金森病（PD）的非运动症状仍有很多未知之处，这些症状在患者中的发生率，进展和严重程度各不相同。现有的神经成像工具套件已经产生了传统方法（如行为和死后评估）无法获得的洞察力。它们提供了关于大脑活动和结构的信息，这对于理解与PD神经变性相关的异常是非常宝贵的。在这些工具中，功能磁共振成像（fMRI）往往是其安全性和空间分辨率的青睐。静息状态功能磁共振成像研究利用了当一个人不执行运动或认知任务时大脑提供的丰富信息。它也是研究受损和异质性人群（如PD患者）的良好手段。本文综述了静息状态下功能磁共振成像的研究，正在进行的狩猎PD非运动症状的生物标志物。到目前为止，这一子领域的研究集中在两个最常见和最重要的非运动症状：认知障碍和抑郁症。这些研究支持静息状态fMRI作为研究这些症状的有效且实用的工具，但研究结果之间的差异凸显了采用标准化程序进行进一步研究的重要性。本文的在线版本（doi：10.1186/2054-7072-1-4）包含补充材料，可供授权用户使用。
Much remains unknown about non-motor symptoms of Parkinson’s disease (PD), which have variable occurrence, progression, and severity among patients. The existing suite of neuroimaging tools has yielded insight that cannot be garnered by traditional methods such as behavioral and post-mortem assessment. They provide information on brain activity and structure that is invaluable to understanding abnormalities associated with neurodegeneration in PD. Among these tools, functional magnetic resonance imaging (fMRI) is often favored for its safety and spatial resolution. Resting state fMRI research capitalizes on the wealth of information that the brain offers when a person is not performing a motor or cognitive task. It is also a good means to study impaired and heterogeneous populations, such as people with PD. The present article reviews research that applies resting state fMRI to the ongoing hunt for biomarkers of PD non-motor symptoms. Thus far, research in this subfield has focused on two of the most common and significant non-motor symptoms: cognitive impairment and depression. These studies support resting state fMRI as a valid and practical tool for the study of these symptoms, but discrepancies among findings highlight the importance of further research with standardized procedures. The online version of this article (doi:10.1186/2054-7072-1-4) contains supplementary material, which is available to authorized users.