PRESENCE OF HOST‐REACTIVE T CELLS IN LYMPHOHEMATOPOIETIC CHIMERAS
PRESENCE OF HOST‐REACTIVE T CELLS IN LYMPHOHEMATOPOIETIC CHIMERAS
复制标题
淋巴细胞造血嵌合体中存在宿主反应性 T 细胞
DOI：
10.1111/j.1749-6632.1982.tb36152.x
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发表时间：
1982
影响因子：
5.2
通讯作者：
R. Dutton
中科院分区：
文献类型：
--
作者：
J. Waterfield;I. King;R. Dutton
在小鼠淋巴造血嵌合体中研究了自身反应性淋巴细胞的存在。在这份报告中，我们证明了存在的母体反应性细胞毒性效应T淋巴细胞的前体导致F1嵌合体。来自这些嵌合体的淋巴细胞在用多克隆T细胞活化剂伴刀豆球蛋白A活化后显示出对宿主的非共有主要组织相容性复合体（MHC）抗原的细胞毒性活性。尽管在其他实验系统中明显缺乏淋巴细胞显示自身反应性，但仍发现了这些宿主反应性细胞：混合淋巴细胞反应、细胞介导的淋巴细胞溶解、阳性同种异体效应和阴性同种异体效应。具有这些细胞毒性效应细胞前体的动物也具有能够产生MHC限制性抗次要组织相容性抗原应答的细胞毒性效应细胞前体。结果进行了讨论，在参考的作用，胸腺在影响自我非自我歧视。
The presence of autoreactive lymphocytes was investigated in murine lymphohaematopoietic chimeras. In this report we demonstrate the presence of precursors of host-reactive cytotoxic effector T lymphocytes in parent leads to F1 chimeras. Lymphocytes from these chimeras display cytotoxic activity towards the non-shared major histocompatibility complex (MHC) antigens of the host following activation with the polyclonal T-cell activator concanavalin A. These host-reactive cells were found despite the apparent absence of lymphocytes demonstrating autoreactivity in other experimental systems: mixed lymphocyte reaction, cell-mediated lympholysis, positive allogeneic effect and negative allogeneic effect. Animals possessing precursors of these cytotoxic effector cells also possess precursors of cytotoxic effector cells capable of generating an MHC-restricted anti-minor histocompatibility antigen response. The results are discussed in reference to the role of the thymus in effecting self non-self discrimination.