Dietary sodium restriction prevents vascular endothelial growth factor inhibitor-induced hypertension.
Dietary sodium restriction prevents vascular endothelial growth factor inhibitor-induced hypertension.
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DOI：
10.1038/s41416-022-02036-6
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发表时间：
2023-01
影响因子：
8.8
通讯作者：
Versmissen, Jorie
中科院分区：
文献类型：
--
作者：
van Doorn, Leni;Visser, Wesley J.;van Dorst, Daan C. H.;Mirabito Colafella, Katrina M.;Koolen, Stijn L. W.;van Egmond-de Mik, Anneke;Garrelds, Ingrid M.;Bovee, Dominique M.;Oomen-de Hoop, Esther;Bins, Sander;Eskens, Ferry A. L. M.;Hoorn, Ewout J.;Jan Danser, A. H.;Mathijssen, Ron H. J.;Versmissen, Jorie
血管内皮生长因子抑制剂（VEGFIs）是一种有效的抗肿瘤药物，常引起高血压. VEGF诱导的高血压在动物研究中是钠敏感的。因此，研究了饮食钠限制（DSR）预防癌症患者中VEGF诱导的高血压的功效。患有VEGF诱导的高血压（日平均值>135/85 mmHg或收缩压和/或舒张压升高≥ 20 mmHg）的癌症患者接受DSR治疗（旨在<4 g盐/天）。主要终点是有DSR和无DSR治疗周期之间日间平均动脉血压（MAP）升高的差异。在没有DSR的第一个VEGFI治疗周期期间，平均日间MAP从95 mmHg增加到110 mmHg。在随后的DSR治疗周期中，平均日间MAP从94 mmHg升高至102 mmHg。因此，DSR使平均日间MAP的增加减弱了7 mmHg（95% CI 1.3-12.0，P = 0.009）。DSR预防了内皮素-1/肾素比值的升高，这通常伴随VEGF诱导的高血压（P = 0.020），并预防了蛋白尿的发生：DSR为0.15（0.10-0.25）g/24 h，而无DSR为0.19（0.11-0.32）g/24 h; P = 0.005。DSR显著减弱VEGFI诱导的血压升高和蛋白尿，因此是一种有效的非药物干预。
Vascular endothelial growth factor inhibitors (VEGFIs) are effective anticancer agents which often induce hypertension. VEGFI-induced hypertension is sodium-sensitive in animal studies. Therefore, the efficacy of dietary sodium restriction (DSR) to prevent VEGFI-induced hypertension in cancer patients was studied. Cancer patients with VEGFI-induced hypertension (day mean >135/85 mmHg or a rise in systolic and/or diastolic BP ≥ 20 mmHg) were treated with DSR (aiming at <4 g salt/day). The primary endpoint was the difference in daytime mean arterial blood pressure (MAP) increase between the treatment cycle with and without DSR. During the first VEGFI treatment cycle without DSR, mean daytime MAP increased from 95 to 110 mmHg. During the subsequent treatment cycle with DSR, mean daytime MAP increased from 94 to 102 mmHg. Therefore, DSR attenuated the increase in mean daytime MAP by 7 mmHg (95% CI 1.3–12.0, P = 0.009). DSR prevented the rise in the endothelin-1/renin ratio that normally accompanies VEGFI-induced hypertension (P = 0.020) and prevented the onset of proteinuria: 0.15 (0.10–0.25) g/24 h with DSR versus 0.19 (0.11–0.32) g/24 h without DSR; P = 0.005. DSR significantly attenuated VEGFI induced BP rise and proteinuria and thus is an effective non-pharmacological intervention.
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影响因子：
8.3
作者：
Kappers, Mariette H. W.;Smedts, Frank M. M.;van den Meiracker, Anton H.
通讯作者：
van den Meiracker, Anton H.
影响因子：
8.3
作者：
Birukov, Anna;Andersen, Louise Bjorkholt;Jensen, Boye L.
通讯作者：
Jensen, Boye L.
影响因子：
6.1
作者：
Lankhorst, Stephanie;Baelde, Hans J.;van den Meiracker, Anton H.
通讯作者：
van den Meiracker, Anton H.
影响因子：
120.1
作者：
Ferrara, Napoleone;Adamis, Anthony P.
通讯作者：
Adamis, Anthony P.
DOI：
10.1152/ajprenal.2001.281.1.f144
发表时间：
2001-07-01
影响因子：
4.2
作者：
Pollock, DM;Pollock, JS
通讯作者：
Pollock, JS