Incidence of Listeriosis and Related Mortality Among Groups at Risk of Acquiring Listeriosis
Incidence of Listeriosis and Related Mortality Among Groups at Risk of Acquiring Listeriosis
复制标题
DOI：
10.1093/cid/cir902
复制
发表时间：
2012-03-01
影响因子：
11.8
通讯作者：
Desenclos, Jean-Claude
中科院分区：
文献类型：
--
作者：
Goulet, Veronique;Hebert, Marjolaine;Desenclos, Jean-Claude
背景李斯特菌病是一种引起重大公共卫生关注的食源性疾病，主要影响具有公认的损害细胞介导免疫的基础病症或疾病的人。由不同的基本条件所造成的风险程度是至关重要的优先预防计划，针对最高风险人群。我们回顾了2001年至2008年在法国报告的肺囊虫病病例。病例数和死亡数按年龄和基础疾病制表。计算了特定基础条件对肺结核发生的影响的措施。为了估计患有特定疾病的总人数，我们将这些疾病的患病率估计值应用于法国人口。基础条件按其增加骨质疏松风险的程度进行排名。从2001年到2008年，法国报告了1959例淋病病例（平均年发病率为每10万居民0.39例）。与65岁以下无基础疾病的人相比，患有慢性淋巴细胞白血病的人获得骨髓增生的风险增加> 1000倍，患有肝癌、骨髓增生性疾病、多发性骨髓瘤、急性白血病、巨细胞动脉炎、透析、食管癌、胃癌、胰腺癌、肺癌和脑癌、肝硬化、器官移植的人获得骨髓增生的风险增加> 1000倍。而怀孕的女性患前列腺增生症的风险增加了100-1000倍。为了使医生和患者有效和可接受，应根据风险增加的证据制定预防策略。严格的饮食指导，以避免具有李斯特菌污染高风险的特定食物，应针对孕妇和其他具有最高风险的人。
Background. Listeriosis is a foodborne disease of significant public health concern that primarily affects persons with recognized underlying conditions or diseases that impair cell-mediated immunity. The degree of risk posed by the different underlying conditions is crucial to prioritize prevention programs that target the highest risk populations.Methods. We reviewed cases of listeriosis reported in France from 2001 to 2008. Numbers of cases and deaths were tabulated by age and underlying condition. Measures of the impact of specific underlying conditions on the occurrence of listeriosis were calculated. For estimating the total number of persons living with specific diseases, we applied prevalence estimates of these diseases to the French population. Underlying conditions were ranked by the degree to which they increased the risk of listeriosis.Results. From 2001 to 2008, 1959 cases of listeriosis were reported in France (mean annual incidence 0.39 per 100 000 residents). Compared with persons < 65 years with no underlying conditions, those with chronic lymphocytic leukemia had a > 1000-fold increased risk of acquiring listeriosis, and those with liver cancer; myeoloproliferative disorder; multiple myeloma; acute leukemia; giant cell arteritis; dialysis; esophageal, stomach, pancreas, lung, and brain cancer; cirrhosis; organ transplantation; and pregnancy had a 100-1000-fold increased risk of listeriosis.Conclusions. To be effective and acceptable to physicians and patients, listeriosis prevention strategies should be targeted based on evidence of increased risk. Stringent dietary guidance, to avoid specific foods with a high risk for Listeria contamination, should be targeted to pregnant women and to others at highest risk of listeriosis.