Synthesis of novel antitumor agent 1-methoxy-5,10- dioxo-5,10-dihydro-1H-benzo[g]isochromene carboxylic acid (3-dimethylylaminopropyl)amide with a dual role Pd(II) catalyst.
Synthesis of novel antitumor agent 1-methoxy-5,10- dioxo-5,10-dihydro-1H-benzo[g]isochromene carboxylic acid (3-dimethylylaminopropyl)amide with a dual role Pd(II) catalyst.
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DOI：
10.1021/jo035016x
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发表时间：
2003-11
期刊：
影响因子：
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通讯作者：
Somnath Mondal;Tsutomu Nogami;N. Asao;Yoshinori Yamamoto
中科院分区：
文献类型：
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作者：
Somnath Mondal;Tsutomu Nogami;N. Asao;Yoshinori Yamamoto
报道了1-甲氧基-5，10-二氧代-5，10-二氢-1H-苯并[g]异色烯-3-羧酸（3-二甲氨基）丙基酰胺4c的简便合成方法。关键的一步是在双功能Pd（II）催化剂作用下，容易地生成异色烯天然产物的重要骨架1，3-二取代环烯基醚。
A convenient and simple method for the synthesis of 1-methoxy-5,10-dioxo-5,10-dihydro-1H-benzo[g]isochromene-3-carboxylic acid (3-(dimethylamino)propyl)amide 4c was developed. The key step involves the easy formation of 1,3-disubstituted cyclic alkenyl ether, an important framework of isochromene natural products, with a dual role Pd(II) catalyst.