HISTOCHEMICAL RESPONSES AT A BIOMATERIALS INTERFACE
HISTOCHEMICAL RESPONSES AT A BIOMATERIALS INTERFACE
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DOI：
10.1002/jbm.820080307
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发表时间：
1974-01-01
期刊：
影响因子：
--
通讯作者：
PASCHALL, HA
中科院分区：
文献类型：
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作者：
HENCH, LL;PASCHALL, HA
描述了一系列无孔玻璃和玻璃材料，其设计具有受控的表面离子活性以允许与骨化学键合。这些材料在体外的表面反应性与体内和组织培养中的生物活性相关。证明了材料与骨的直接化学结合。该键的形成机制是通过在玻璃上产生无定形离子表面凝胶。该凝胶通过成骨细胞的趋化反应诱导骨生成。
A series of nonporous glasses and glass materials designed with controlled surface ion activities to allow chemical bonding to bone are described. Surface reactivities of these materials in vitro are correlated with biological activities in vivo and in tissue culture. Direct chemical bonding of the materials to bone is demonstrated. The mechanism for development of this bond is through the production of an amorphous ion surface gel on the bioglass. This gel induces osteogenesis by a chemotactic response of osteoblasts.