Fatty acids in plasma phospholipids and cholesterol esters from identical twins concordant and discordant for schizophrenia
Fatty acids in plasma phospholipids and cholesterol esters from identical twins concordant and discordant for schizophrenia
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同卵双胞胎血浆磷脂和胆固醇酯中的脂肪酸与精神分裂症一致和不一致
DOI：
10.1016/0920-9964(91)90014-i
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发表时间：
1991
影响因子：
4.5
通讯作者：
K. Ells
中科院分区：
文献类型：
--
作者：
C. Bates;D. Horrobin;K. Ells
研究人员测量了 18 对精神分裂症不一致的双胞胎和 20 对精神分裂症一致的双胞胎的血浆磷脂和胆固醇酯的脂肪酸组成。在精神分裂症不一致的双胞胎中，唯一显着的异常是精神分裂症双胞胎中肾上腺 (22:4n-6) 和二十二碳五烯酸 (22:5n-6) 的升高。最近也有报道称，精神分裂症患者大脑中的这些脂肪酸含量有所升高。精神分裂症一致的双胞胎与正常的不一致双胞胎表现出许多差异。 22:4n-6 和 22:5n-6 甚至比精神分裂症不一致双胞胎更加异常。此外，亚油酸显着减少，这种异常现象在其他精神分裂症人群中也得到了一致的发现。这些观察结果与精神分裂症患者不饱和脂肪代谢可能异常的概念是一致的。
The fatty acid compositions of plasma phospholipids and cholesterol esters were measured in 18 pairs of twins discordant for schizophrenia and 20 pairs concordant for schizophrenia. In the twins discordant for schizophrenia the only significant abnormalities were elevations of adrenic (22:4n-6) and docosapentaenoic (22:5n-6) acids in the schizophrenic twins. These fatty acids have also recently been reported to be elevated in brains from schizophrenics. The twins concordant for schizophrenia showed many differences from the normal discordant twins. 22:4n-6 and 22:5n-6 were even more abnormal than in the schizophrenic discordant twins. In addition, linoleic acid was significantly reduced, an abnormality which has been found consistently in other schizophrenic populations. These observations are consistent with the concept that unsaturated fat metabolism may be abnormal in schizophrenia.
DOI：
10.1056/nejm199003223221201
发表时间：
1990-03
期刊：
The New England journal of medicine
影响因子：
--
作者：
R. Suddath;G. Christison;E. Torrey;M. Casanova;D. Weinberger
通讯作者：
R. Suddath;G. Christison;E. Torrey;M. Casanova;D. Weinberger