Case-control study of risk factors of myelodysplastic syndromes according to World Health Organization classification in a Chinese population
Case-control study of risk factors of myelodysplastic syndromes according to World Health Organization classification in a Chinese population
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DOI：
10.1002/ajh.21941
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发表时间：
2011-02-01
影响因子：
12.8
通讯作者：
Bao, Liming
中科院分区：
文献类型：
--
作者：
Lv, Ling;Lin, Guowei;Bao, Liming
骨髓增生异常综合征（MDS）的危险因素仍然很大程度上未知。我们进行了一项以医院为基础的病例对照研究，由来自中国上海 27 家主要医院的 403 名根据世界卫生组织分类的新诊断 MDS 患者和 806 名性别和年龄匹配的患者对照组成，以探讨生活方式、环境和职业因素与 MDS 风险的关系。研究表明，所有MDS（所有亚型组合）危险因素均包括抗结核药物[比值比(OR)(adj) = 3.15； 95% 置信区间 (CI) = 1.22-8.12] 作为独立危险因素，苯（ORadj = 3.73；95% CI = 1.32-10.51）、染发剂使用（OR = 1.46；95% CI = 1.03-2.07）、新建和翻修（OR = 1.69；95% CI = 1.11-2.00）、杀虫剂（OR = 2.16；95% CI = 1.22-3.82）和除草剂（OR = 5.33；95% CI = 1.41-20.10）作为相对危险因素。 MDS亚型难治性血细胞减少伴多发性不典型增生（RCMD）的独立危险因素为苯（ORadj = 5.99；95% CI = 1.19-30.16）和汽油（ORadj = 11.44；95% CI = 1.31-100.03），中药（OR = 2.17；95% CI = 1.19-30.16）为独立危险因素。 1.15-4.07）、杀虫剂（OR = 2.92；95% CI = 1.37-6.25）和除草剂（OR = 12.00；95% CI = 1.44-99.67）作为相对危险因素。吸烟与原始细胞过多的难治性贫血 (RAEB) 显着相关（ORadj = 2.43；95% CI = 1.02-5.77）。教育被证明是针对所有 MDS（ORadj = 0.90；95% CI = 0.83-0.99）和 RCMD（ORadj = 0.89；95% CI = 0.79-0.99）的独立保护因素。这些研究结果表明，多种可改变的行为、环境和职业因素在MDS病因学中发挥着作用，并且各种MDS亚型可能具有不同的易感性。是。 J.赫马托尔。 86:163-169, 2011。(C) 2010 Wiley-Liss, Inc.
Risk factors of mydelodysplastic syndromes (MDS) remain largely unknown. We conducted a hospital-based case-control study consisting of 403 newly diagnosed MDS patients according to World Health Organization classification and 806 individually gender and age-matched patient controls from 27 major hospitals in Shanghai, China, to examine relation of lifestyle, environmental, and occupational factors to risk of MDS. The study showed that all MDS (all subtypes combined) risk factors included anti tuberculosis drugs [odds ratio (OR)(adj) = 3.15; 95% confidence interval (CI) = 1.22-8.12] as an independent risk factor, benzene (ORadj = 3.73; 95% CI = 1.32-10.51), hair dye use (OR = 1.46; 95% CI = 1.03-2.07), new building and renovations (OR = 1.69; 95% CI = 1.11-2.00), pesticides (OR = 2.16; 95% CI = 1.22-3.82), and herbicides (OR = 5.33; 95% CI = 1.41-20.10) as relative risk factors. Risk factors of MDS subtype refractory cytopenia with multiple dysplasia (RCMD) were benzene (ORadj = 5.99; 95% CI = 1.19-30.16) and gasoline (ORadj = 11.44; 95% CI = 1.31-100.03) as independent risk factors, and traditional Chinese medicines (OR = 2.17; 95% CI = 1.15-4.07), pesticides (OR = 2.92; 95% CI = 1.37-6.25), and herbicides (OR = 12.00; 95% CI = 1.44-99.67) as relative risk factors. Smoking tobacco was significantly associated with refractory anemia with excess of blasts (RAEB) (ORadj = 2.43; 95% CI = 1.02-5.77). Education is shown as an independent protective factor against all MDS (ORadj = 0.90; 95% CI = 0.83-0.99) and RCMD (ORadj = 0.89; 95% CI = 0.79-0.99). These findings suggest that multiple modifiable behavioral, environmental, and occupational factors play a role in MDS etiology, and various MDS subtypes may have different susceptibility. Am. J. Hematol. 86:163-169, 2011. (C) 2010 Wiley-Liss, Inc.