ceRNA cross-talk in cancer: when ce-bling rivalries go awry.
ceRNA cross-talk in cancer: when ce-bling rivalries go awry.
复制标题
DOI：
10.1158/2159-8290.cd-13-0202
复制
发表时间：
2013-10
期刊：
影响因子：
28.2
通讯作者：
Pandolfi PP
中科院分区：
文献类型：
--
作者：
Karreth FA;Pandolfi PP
癌症转录组的特征在于蛋白质编码和非编码转录物的异常表达。与mRNA类似，非编码转录组的显著部分（包括长的非编码RNA和假基因）具有微RNA响应元件。最近发现的竞争性内源性RNA（ceRNA），天然诱饵，竞争一个共同的池的microRNA，提供了一个框架，系统功能化MRE窝藏非编码RNA，并将它们与蛋白质编码RNA的复杂ceRNA网络的尺寸。ceRNA网络中的功能相互作用有助于协调许多生物过程，并且当受到干扰时，有助于疾病的发病机制。在这篇综述中，我们讨论了最近的发现，牵连天然miRNA诱饵在癌症的发展。
The cancer transcriptome is characterized by aberrant expression of both protein-coding and non-coding transcripts. Similar to mRNAs, a significant portion of the non-coding transcriptome including long non-coding RNAs and pseudogenes harbors microRNA-response elements. The recent discovery of competitive endogenous RNAs (ceRNA), natural decoys that compete for a common pool of microRNAs, provides a framework to systematically functionalize MRE-harboring non-coding RNAs and integrate them with the protein-coding RNA dimension in complex ceRNA networks. Functional interactions in ceRNA networks aid coordinating a number of biological processes and, when perturbed, contribute to disease pathogenesis. In this review, we discuss recent discoveries that implicate natural miRNA decoys in the development of cancer.