Mood disorders following traumatic brain injury
Mood disorders following traumatic brain injury
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DOI：
10.1080/09540260310001606700
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发表时间：
2003-11-01
影响因子：
2.8
通讯作者：
Robinson, RG
中科院分区：
文献类型：
--
作者：
Jorge, R;Robinson, RG
情绪障碍是创伤性脑损伤的常见并发症，对脑损伤患者的恢复过程和心理社会结果产生有害影响。既往精神病史和受损的社会支持一直被报道为创伤性脑损伤（TBI）后发生心境障碍的危险因素。此外，生物学因素，如前额叶皮质和其他边缘系统和边缘系统结构的参与可能在这些疾病的复杂病理生理学中发挥重要作用。初步研究表明，选择性5-羟色胺再摄取抑制剂（如舍曲林）、情绪稳定剂（如丙戊酸钠）以及兴奋剂和ECT可能有助于治疗这些疾病。创伤性脑损伤后发生的情绪障碍显然是神经精神病学的一个领域，在病因学和治疗方面需要进一步的研究。
Mood disorders are a frequent complication of traumatic brain injury that exerts a deleterious effect on the recovery process and psychosocial outcome of brain injured patients. Prior psychiatric history and impaired social support have been consistently reported as risk factors for developing mood disorders after traumatic brain injury (TBI). In addition, biological factors such as the involvement of the prefrontal cortex and probably other limbic and paralimbic structures may play a significant role in the complex pathophysiology of these disorders. Preliminary studies have suggested that selective serotonin reuptake inhibitors such as sertraline, mood stabilizers such as sodium valproate, as well as stimulants and ECT may be useful in treating these disorders. Mood disorders occurring after TBI are clearly an area of neuropsychiatry in which further research in etiology as well as treatment is needed.