Hepatitis C Virus Is Infrequently Evaluated and Treated in an Urban HIV Clinic Population
Hepatitis C Virus Is Infrequently Evaluated and Treated in an Urban HIV Clinic Population
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DOI：
10.1089/apc.2009.0099
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发表时间：
2009-11-01
影响因子：
4.9
通讯作者：
Wang, Chia C.
中科院分区：
文献类型：
--
作者：
Scott, John D.;Wald, Anna;Wang, Chia C.
这项针对HIV/丙型肝炎病毒(丙型肝炎病毒)混合感染患者的回顾性队列研究评估了1997年1月1日至2004年10月30日期间就诊的患者的丙型肝炎病毒评估的时间趋势和比率。生存分析和Cox比例风险模型被用来描述评估的时间和与此结果相关的协变量。患者主要是白人和男性。在248名符合条件的患者中，108名(44%)接受了丙型肝炎病毒治疗评估。中位评估时间为2.98年。在接受评估的108人中，17人(16%)接受了至少一剂干扰素和/或利巴韦林。评估后接受治疗的中位时间为1.39年。在接受治疗的17名患者中，有6名患者有持续的病毒学应答，但只有2.4%的患者被治愈。在HIV专科诊所中，大约一半的患者接受了丙型肝炎病毒治疗的评估，16%的患者接受了治疗，但从丙型肝炎病毒诊断时间到治疗的中位数时间超过了4年。有必要进一步努力识别和克服丙型肝炎治疗的障碍。
This retrospective cohort study of HIV/hepatitis C virus (HCV) coinfected patients evaluated time trends and rates of HCV evaluation for patients seen between January 1, 1997 and October 30, 2004. Survival analysis and Cox proportional hazards modeling were used to describe the time to evaluation and covariates associated with this outcome. Patients were predominantly white and male. Of 248 eligible patients, 108 ( 44%) were evaluated for HCV treatment. The median time to evaluation was 2.98 years. Of 108 evaluated, 17 (16%) received at least one dose of interferon and/or ribavirin. The median time to treatment after being evaluated was 1.39 years. Of the 17 (35%) treated 6 patients had a sustained virologic response, but only 2.4% of the original number of patients were cured. Approximately one half of patients in an HIV-specialty clinic were evaluated for HCV therapy and 16% received treatment, but the median time to treatment from the time of HCV diagnosis was over 4 years. Further efforts to identify and to overcome barriers to HCV treatment are warranted.