Potential renal and hepatic toxicity of diphenyl diselenide, diphenyl ditelluride and Ebselen for rats and mice
Potential renal and hepatic toxicity of diphenyl diselenide, diphenyl ditelluride and Ebselen for rats and mice
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DOI：
10.1016/s0378-4274(03)00090-0
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发表时间：
2003-06-05
影响因子：
3.5
通讯作者：
Nogueira, CW
中科院分区：
文献类型：
--
作者：
Meotti, FC;Borges, VC;Nogueira, CW
碲和硒的职业重要性正在迅速增长，但对接触的生物化学知之甚少。本文报道了二苯二硒（PhSe）（2）、二苯二碲（PhTe）（2）和依布硒啉对大鼠和小鼠的潜在毒性作用。结果表明，（PhTe）（2）对大鼠的毒性大于小鼠。（PhSe）（2）、（PhTe）（2）和依布硒啉经腹腔（i. p.）皮下（s.c.）路线（PhTe）（2），i，p.，在大鼠中为0.65 mumol/kg，在小鼠中为150 mumol/kg，在大鼠中为0.9 mumol/kg，在小鼠中为> 500 mumol/kg。依布硒啉（i. p.）的LD 50计算值，在大鼠中为400 mumol/kg，在小鼠中为340 mumol/kg，在小鼠和大鼠中均> 500 mumol/kg。（PhTe）（2）在小剂量时使血清丙氨酸氨基转移酶增加2倍。(ALT)和天冬氨酸氨基转移酶（AST）活性。所有有机硫属元素在小鼠中给药的LD 50抑制血液中的δ-ALA-D活性。本研究为（PhTe）的肝和肾毒性提供了证据（2）。(C)2003爱思唯尔科学爱尔兰有限公司保留所有权利。
The occupational importance of tellurium and selenium is growing rapidly, but the biochemistry of exposure is poorly understood. Here we report the potential toxic effects of diphenyl diselenide (PhSe)(2), diphenyl ditelluride (PhTe)(2) and Ebselen in rats and mice. The results suggest that (PhTe)(2) is more toxic in rats than mice. (PhSe)(2), (PhTe)(2) and Ebselen are more toxic by intraperitoneal (i.p.) than subcutaneous (s.c.) route. Calculated LD50 for (PhTe)(2), i,p., was 0.65 mumol/kg in rats and 150 mumol/kg in mice, and LD50, s.c., was 0.9 mumol/kg in rats and > 500 mumol/kg in mice. Calculated LD50 for Ebselen, i.p., was 400 mumol/kg in rats and 340 mumol/kg in mice and LD50, s.c., was > 500 mumol/kg in both mice and rats. (PhTe)(2) at small doses increased 2-fold serum alanine aminotransferase. (ALT) and aspartate aminotransferase (AST) activities in rats. LD50 for all organochalcogens administrated in mice inhibited blood delta-ALA-D activity. The present study provides evidence for liver and renal toxicity of (PhTe)(2). (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.