The Impact of microRNAs in Renin-Angiotensin-System-Induced Cardiac Remodelling.
The Impact of microRNAs in Renin-Angiotensin-System-Induced Cardiac Remodelling.
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DOI：
10.3390/ijms22094762
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发表时间：
2021-04-30
影响因子：
5.6
通讯作者：
Simko F
中科院分区：
文献类型：
--
作者：
Adamcova M;Kawano I;Simko F
目前对肾素-血管紧张素系统(RAS)的研究表明，RAS通过血流动力学改变和直接生长，以及血管紧张素II或醛固酮的增殖效应，导致心肌细胞肥大、成纤维细胞增殖和炎性免疫细胞激活，在心血管重塑的发病机制中发挥核心作用。最近，非编码调控microRNAs成为研究RAS的一种全新的方法。越来越多的microRNAs通过直接靶向RAS酶、受体、信号分子或信号通路抑制物，作为RAS诱导的心脏重塑的介体和/或调节器。具体地说，直接调节血管紧张素II受体1型(AT1R)刺激启动的促肥大、促纤维化和促炎信号的microRNAs在介导RAS的心血管效应方面具有特别的相关性。这篇综述的目的是总结目前该领域的知识，这些知识仍处于临床前研究的早期阶段，偶尔会有相互矛盾的报告。了解microRNAs的整体情况不仅有助于更好地了解心脏对损伤的反应，还有助于更好地利用microRNAs作为生物标记物、治疗剂和药理靶点的治疗策略。
Current knowledge on the renin–angiotensin system (RAS) indicates its central role in the pathogenesis of cardiovascular remodelling via both hemodynamic alterations and direct growth and the proliferation effects of angiotensin II or aldosterone resulting in the hypertrophy of cardiomyocytes, the proliferation of fibroblasts, and inflammatory immune cell activation. The noncoding regulatory microRNAs has recently emerged as a completely novel approach to the study of the RAS. A growing number of microRNAs serve as mediators and/or regulators of RAS-induced cardiac remodelling by directly targeting RAS enzymes, receptors, signalling molecules, or inhibitors of signalling pathways. Specifically, microRNAs that directly modulate pro-hypertrophic, pro-fibrotic and pro-inflammatory signalling initiated by angiotensin II receptor type 1 (AT1R) stimulation are of particular relevance in mediating the cardiovascular effects of the RAS. The aim of this review is to summarize the current knowledge in the field that is still in the early stage of preclinical investigation with occasionally conflicting reports. Understanding the big picture of microRNAs not only aids in the improved understanding of cardiac response to injury but also leads to better therapeutic strategies utilizing microRNAs as biomarkers, therapeutic agents and pharmacological targets
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DOI：
10.1073/pnas.1206432109
发表时间：
2012-10-23
影响因子：
11.1
作者：
Bernardo, Bianca C.;Gao, Xiao-Ming;McMullen, Julie R.
通讯作者：
McMullen, Julie R.
MicroRNA 作为心脏重构的治疗靶点
影响因子：
--
作者：
Chen C;Ponnusamy M;Liu C;Gao J;Wang K;Li P
通讯作者：
Li P
影响因子：
4.1
作者：
Butterworth MB
通讯作者：
Butterworth MB
影响因子：
30.8
作者：
Chen, JF;Mandel, EM;Wang, DZ
通讯作者：
Wang, DZ
影响因子：
37.8
作者：
Bendall, JK;Cave, AC;Shah, AM
通讯作者：
Shah, AM