Evaluation of hyperreflective foci as a prognostic factor of visual outcome in retinal vein occlusion
Evaluation of hyperreflective foci as a prognostic factor of visual outcome in retinal vein occlusion
复制标题
DOI：
10.18240/ijo.2017.04.17
复制
发表时间：
2017-04-18
影响因子：
1.4
通讯作者：
Zhang, Feng
中科院分区：
文献类型：
--
作者：
Mo, Bin;Zhou, Hai-Ying;Zhang, Feng
目的：评估高反射灶 (HF) 作为视网膜静脉阻塞 (RVO) 所致黄斑水肿 (ME) 患者视力预后指标的潜在作用。 方法：我们回顾性分析了 50 例缺血性视网膜中央静脉阻塞 (CRVO)、非缺血性 CRVO 和视网膜分支静脉阻塞 (BRVO) 所致 ME 患者的 50 只眼。 2013年1月至2016年7月在北京同仁眼科中心接受抗血管内皮生长因子（抗VEGF）治疗。所有患者在基线和随访时均接受最佳矫正视力（BCVA）、谱域光学相干断层扫描（SD-OCT）。对三组的基线和最终BCVA、中央视网膜厚度（CRT）、外界膜（ELM）状态以及不同位置的HF数量等因素进行评估和比较。采用多元线性回归分析来分析基线 HF 和最终 BCVA 之间的关系。并评价治疗前后HF的变化。结果：三组中HF均可位于视网膜各层及玻璃体腔内。基线时视网膜外层 (ORL) 的平均 HF 在具有完整 ELM 的缺血性 CRVO 中为 5.29 +/- 8.48，在非缺血性 CRVO 中为 1.93 +/- 2.76，在 BRVO 中为 1.75 +/- 2.05。随着 ELM 的破坏，ORL 中的平均 HF 增加。完整的ELM和破坏的ELM之间的ORL中的HF存在统计学差异。在三组中，ORL 中的 HF 数量与视力结果不佳相关。然而，视网膜内层 (IRL) 和玻璃体腔的 HF 与不良视力结果无关。同时，抗VEGF治疗后，非缺血性CRVO和BRVO中ORL和玻璃体腔的基线HF显着降低。结论：ORL中HF的数量是RVO ME患者抗VEGF治疗后与最终BCVA相关的预后因素。
AIM: To evaluate the potential role of hyperreflective foci (HF) as a prognostic indicator of visual outcome in patients with macular edema (ME) due to retinal vein occlusion (RVO).METHODS: We retrospectively reviewed 50 eyes of 50 patients with ME due to ischemic central retinal vein occlusion (CRVO), non-ischemic CRVO and branch retinal vein occlusion (BRVO) who were treated with anti-vascular endothelial growth factor (anti-VEGF) at Beijing Tongren Eye Center from January 2013 to July 2016. All patients underwent best-corrected visual acuity (BCVA), spectral domain optical coherence tomography (SD-OCT) at baseline and follow-up. Such factors were evaluated and compared among three groups as baseline and final BCVA, central retinal thickness (CRT), external limiting membrane (ELM) status and the numbers of HF in different position. Multiple linear regression analysis was employed to analyze the relationship between baseline HF and final BCVA. Changes of HF before and after treatment were evaluated too.RESULTS: Among three groups, HF could be located in each retinal layers, as well as in vitreous cavity. The mean HF in outer retinal layer (ORL) at baseline was 5.29 +/- 8.48 in ischemic CRVO with intact ELM, 1.93 +/- 2.76 in non-ischemic CRVO, and 1.75 +/- 2.05 in BRVO. With disrupted ELM, the mean HF in ORL increased. There was statistically difference of HF in ORL between intact and disrupted ELM. The numbers of HF in ORL were associated with poor visual outcome among three groups. However, HF in inner retinal layer (IRL) and vitreous cavity were not associated with poor visual outcome. Meanwhile, the baseline HF in ORL and vitreous cavity reduced significantly in non-ischemic CRVO and BRVO after anti-VEGF treatment.CONCLUSION: The numbers of HF in ORL are prognostic factors associated with the final BCVA in patients with ME due to RVO after anti-VEGF treatment.