Glycinergic projection neurons of the cerebellum.
Glycinergic projection neurons of the cerebellum.
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DOI：
10.1523/jneurosci.2087-09.2009
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发表时间：
2009-08-12
期刊：
影响因子：
--
通讯作者：
du Lac S
中科院分区：
文献类型：
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作者：
Bagnall MW;Zingg B;Sakatos A;Moghadam SH;Zeilhofer HU;du Lac S
小脑通过小脑深部核团中的少数推测的谷氨酸能运动前投射神经元和反馈到下橄榄的GABA能神经元将其整个输出汇集起来。在这里，我们使用转基因小鼠选择性地表达绿色荧光蛋白（GFP）的甘氨酸能神经元，以证明许多运动前输出神经元在内侧小脑（顶）核实际上是甘氨酸能，而不是以前认为的谷氨酸能。这些神经元表现出与相邻的海马能神经元相似的放电特性，并接受来自浦肯野细胞和兴奋性纤维的直接输入。甘氨酸能小脑顶神经元向同侧脑干的前庭和网状神经元进行功能性投射，而它们的海马能对应物则向对侧投射。这些数据表明，小脑可以通过两种不同的互补途径影响运动输出。
The cerebellum funnels its entire output through a small number of presumed glutamatergic premotor projection neurons in the deep cerebellar nuclei and GABAergic neurons that feed back to the inferior olive. Here we use transgenic mice selectively expressing green fluorescent protein (GFP) in glycinergic neurons to demonstrate that many premotor output neurons in the medial cerebellar (fastigial) nuclei are in fact glycinergic, not glutamatergic as previously thought. These neurons exhibit similar firing properties as neighboring glutamatergic neurons and receive direct input from both Purkinje cells and excitatory fibers. Glycinergic fastigial neurons make functional projections to vestibular and reticular neurons in the ipsilateral brainstem, while their glutamatergic counterparts project contralaterally. Together these data suggest that the cerebellum can influence motor outputs via two distinct and complementary pathways.