Thermosensitive Biodegradable Homopolymer of Trimethylene Carbonate Derivative at Body Temperature
Thermosensitive Biodegradable Homopolymer of Trimethylene Carbonate Derivative at Body Temperature
复制标题
DOI：
10.1021/ma300183t
复制
发表时间：
2012-03-27
期刊：
影响因子：
5.5
通讯作者：
Akashi, Mitsuru
中科院分区：
文献类型：
--
作者：
Ajiro, Hiroharu;Takahashi, Yoshikazu;Akashi, Mitsuru
以聚碳酸三亚甲基（PTMC）为骨架，低聚乙二醇（OEG）为原料，制备了一种具有较低体温临界溶解温度（LCST）的热敏可生物降解均聚物。该新型单体是通过OEG与碳酸三亚甲基（TMC）直接连接而设计的，聚合物结构中不存在其他官能团。这样一个定义明确的单体单位促成了它的同质特性。TMC衍生物中的三个单位乙二醇在室温下具有水溶性，在较高温度下溶液变得混浊。LCST范围为31 ~ 35℃，受分子量和聚合物浓度的影响。然而，四个单位的乙二醇将LCST温度提高到72℃。值得注意的是，目前的特性，体温下的热敏性，可生物降解性，以及明确的均聚物结构，是生物医学应用的重要材料。
A thermosensitive biodegradable homopolymer with a lower critical solution temperature (LCST) at body temperature was developed, with a poly(trimethylene carbonate) (PTMC) backbone and oligoethylene glycol (OEG). The novel monomer was designed by the direct connection of OEG into trimethylene carbonate (TMC), and no other functional groups exist in the polymer structure. Such a well-defined monomer unit contributed to its homogeneous characteristics. Three units of ethylene glycol in the TMC derivative resulted in a water-soluble nature at room temperature, and the solution became cloudy at higher temperatures. The LCST ranged from 31 to 35 degrees C and was influenced by the molecular weight and polymer concentration. Four units of ethylene glycol, however, increased the LCST temperature to 72 degrees C. It is noteworthy that the present characteristics, thermosensitivity at body temperature, biodegradablility, and a well-defined homopolymer structure, are promising for biomedical applications as an essential material.